Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313430156> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4313430156 endingPage "116.10" @default.
- W4313430156 startingPage "116.10" @default.
- W4313430156 abstract "Abstract The bacterial pathogen Mycobacterium tuberculosis (Mtb) successfully evades host innate immune responses to cause tuberculosis (TB) disease. Recent studies showed that myeloid-derived suppressor cells (MDSCs) are recruited to the lung after Mtb infection and harbor Mtb. While MDSC-mediated negative regulation of tumor micro-environments in cancer has been extensively studied, in-depth analyses of the phenotype, functions and transcriptional signatures of MDSCs in TB are lacking. In this study we sought to characterize MDSCs in the lungs of Mtb-infected mice and develop tools for depleting MDSCs as a strategy for host-directed therapy. We determined MDSCs in the aerosol mouse model of TB and in human blood using flow cytometry. MDSCs are recruited into the lung as early as 2 weeks post-infection and expresses immunomodulatory mediators associated with immune suppression such as iNOS, IDO and arginase. We recently reported the development of novel synthetic nanoparticle antibodies (SNAbs) that specifically target and deplete MDSCs via antibody-like mechanisms. We used SNAbs to deplete Mtb-induced MDSCs in vitro and in human PBMCs ex vivo. Interestingly, we found that SNAbs efficiently depleted MDSCs in both models. To test the efficacy of SNAb-mediated depletion of MDSCs in mouse lungs in vivo, we first used a murine lung cancer model and found that intra-tracheal delivery of SNAbs successfully depleted MDSCs in vivo. Ongoing studies include evaluating the ability of SNAbs to deplete lung MDSCs following Mtb infection of mice and to assess the impact on lung T cell functions, pathology and Mtb burden. These studies will establish a platform to investigate MDSCs as a target for host-directed therapies that improve TB treatment efficacy. Supported by grant from NIH (1R01AI155023-01A1)" @default.
- W4313430156 created "2023-01-06" @default.
- W4313430156 creator A5005656079 @default.
- W4313430156 creator A5026200791 @default.
- W4313430156 creator A5031324639 @default.
- W4313430156 creator A5031575084 @default.
- W4313430156 creator A5049866648 @default.
- W4313430156 creator A5057300028 @default.
- W4313430156 creator A5078357876 @default.
- W4313430156 creator A5082926857 @default.
- W4313430156 creator A5083506653 @default.
- W4313430156 creator A5090613390 @default.
- W4313430156 date "2022-05-01" @default.
- W4313430156 modified "2023-09-23" @default.
- W4313430156 title "Nanoparticle based depletion of Myeloid-derived Suppressor cells in Tuberculosis" @default.
- W4313430156 doi "https://doi.org/10.4049/jimmunol.208.supp.116.10" @default.
- W4313430156 hasPublicationYear "2022" @default.
- W4313430156 type Work @default.
- W4313430156 citedByCount "0" @default.
- W4313430156 crossrefType "journal-article" @default.
- W4313430156 hasAuthorship W4313430156A5005656079 @default.
- W4313430156 hasAuthorship W4313430156A5026200791 @default.
- W4313430156 hasAuthorship W4313430156A5031324639 @default.
- W4313430156 hasAuthorship W4313430156A5031575084 @default.
- W4313430156 hasAuthorship W4313430156A5049866648 @default.
- W4313430156 hasAuthorship W4313430156A5057300028 @default.
- W4313430156 hasAuthorship W4313430156A5078357876 @default.
- W4313430156 hasAuthorship W4313430156A5082926857 @default.
- W4313430156 hasAuthorship W4313430156A5083506653 @default.
- W4313430156 hasAuthorship W4313430156A5090613390 @default.
- W4313430156 hasConcept C121608353 @default.
- W4313430156 hasConcept C142724271 @default.
- W4313430156 hasConcept C150903083 @default.
- W4313430156 hasConcept C179185449 @default.
- W4313430156 hasConcept C203014093 @default.
- W4313430156 hasConcept C207001950 @default.
- W4313430156 hasConcept C26291073 @default.
- W4313430156 hasConcept C2776156784 @default.
- W4313430156 hasConcept C2776256026 @default.
- W4313430156 hasConcept C2777975735 @default.
- W4313430156 hasConcept C2781069245 @default.
- W4313430156 hasConcept C502942594 @default.
- W4313430156 hasConcept C54355233 @default.
- W4313430156 hasConcept C553184892 @default.
- W4313430156 hasConcept C55721878 @default.
- W4313430156 hasConcept C71924100 @default.
- W4313430156 hasConcept C86803240 @default.
- W4313430156 hasConcept C8891405 @default.
- W4313430156 hasConceptScore W4313430156C121608353 @default.
- W4313430156 hasConceptScore W4313430156C142724271 @default.
- W4313430156 hasConceptScore W4313430156C150903083 @default.
- W4313430156 hasConceptScore W4313430156C179185449 @default.
- W4313430156 hasConceptScore W4313430156C203014093 @default.
- W4313430156 hasConceptScore W4313430156C207001950 @default.
- W4313430156 hasConceptScore W4313430156C26291073 @default.
- W4313430156 hasConceptScore W4313430156C2776156784 @default.
- W4313430156 hasConceptScore W4313430156C2776256026 @default.
- W4313430156 hasConceptScore W4313430156C2777975735 @default.
- W4313430156 hasConceptScore W4313430156C2781069245 @default.
- W4313430156 hasConceptScore W4313430156C502942594 @default.
- W4313430156 hasConceptScore W4313430156C54355233 @default.
- W4313430156 hasConceptScore W4313430156C553184892 @default.
- W4313430156 hasConceptScore W4313430156C55721878 @default.
- W4313430156 hasConceptScore W4313430156C71924100 @default.
- W4313430156 hasConceptScore W4313430156C86803240 @default.
- W4313430156 hasConceptScore W4313430156C8891405 @default.
- W4313430156 hasIssue "1_Supplement" @default.
- W4313430156 hasLocation W43134301561 @default.
- W4313430156 hasOpenAccess W4313430156 @default.
- W4313430156 hasPrimaryLocation W43134301561 @default.
- W4313430156 hasRelatedWork W2078440561 @default.
- W4313430156 hasRelatedWork W2171627501 @default.
- W4313430156 hasRelatedWork W2349894740 @default.
- W4313430156 hasRelatedWork W2761385502 @default.
- W4313430156 hasRelatedWork W2788398649 @default.
- W4313430156 hasRelatedWork W3028987687 @default.
- W4313430156 hasRelatedWork W3093170431 @default.
- W4313430156 hasRelatedWork W4206392491 @default.
- W4313430156 hasRelatedWork W4306839112 @default.
- W4313430156 hasRelatedWork W4377940992 @default.
- W4313430156 hasVolume "208" @default.
- W4313430156 isParatext "false" @default.
- W4313430156 isRetracted "false" @default.
- W4313430156 workType "article" @default.