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• W4313430188 endingPage "169.08" @default.
• W4313430188 startingPage "169.08" @default.
• W4313430188 abstract "Abstract Shortly after priming, the fate of activated CD4 T cells is segregated into BCL6+ follicular helper T (Tfh) and BCL6− effector (Teff) cells. However, it remains unknown how these subsets are sustained in the presence of chronic antigen stimulation. Using a combination of single cell- and population-based approaches, we show that in chronic viral infection, activated CD4 T cells differentiate into BCL6-dependent TCF-1+ progenitor cells with superior capacity to expand and give rise to both Teff and Tfh. They share properties with progenitor-exhausted CD8 T cells and are required for the continued generation of Teff cells as antigen persists. In response to tumors, an analogous CD4 T cell population develops in draining lymph nodes. Our study reveals the heterogeneity and plasticity of CD4 T cells upon encountering persistent antigen and highlights their population dynamics through a stable bipotent intermediate state." @default.
• W4313430188 created "2023-01-06" @default.
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• W4313430188 date "2022-05-01" @default.
• W4313430188 modified "2023-10-18" @default.
• W4313430188 title "BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen" @default.
• W4313430188 doi "https://doi.org/10.4049/jimmunol.208.supp.169.08" @default.
• W4313430188 hasPublicationYear "2022" @default.
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