FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313431348> ?p ?o ?g. }

• W4313431348 abstract "Abstract Objective Population studies have shown that vitamin D (VitD) deficiency is associated with an increased incidence of type 2 diabetes mellitus (T2DM), VitD deficiency is a potential risk factor for T2DM, and the proportion of M1-type macrophages and M2-type macrophages in T2DM patients is imbalanced. Another study reported that VitD can affect the differentiation of macrophages into M1 and M2 types. However, there is no definitive result about the correlation between plasma VitD levels and macrophage typing in patients with T2DM. Whether VitD affects the progression of T2DM by regulating the polarization type of macrophages and the specific regulatory mechanism is not very clear. Therefore, we carried out the following research. Methods We first used flow cytometry to detect the proportions of M1 and M2 macrophages in peripheral blood of T2DM patients with different VitD levels. Furthermore, we used ELISA to detect the inflammatory factors affecting macrophage differentiation in patients’ plasma, including IL-6 secreted by M1-type macrophages and TGF-β secreted by M2-type macrophages. Mononuclear cells were separated from human peripheral blood with immunomagnetic beads, cultured in vitro, and treated with different concentrations of VitD, and the ratio of differentiation into M1 and M2 macrophages was detected by flow cytometry. Results With the increase of serum 25(OH)D levels in patients with T2DM, the proportion of M1 and M2 macrophages in peripheral blood decreased, that is, the polarized phenotype of macrophages was more inclined to M2 type, while plasma IL-6 gradually decreased, and TGF-β gradually increased. In addition, VitD can promote the differentiation of CD14-positive monocytes cultured in vitro into M2 macrophages. Conclusions When the level of VitD in T2DM patients is low, there are more M1-type macrophages in peripheral blood, and when the level of VitD is increased, M2-type macrophages are increased. Changes in related inflammatory factors were also consistent. In vitro culture of monocytes further confirmed that VitD can promote the differentiation of macrophages to M2 type in T2DM patients." @default.
• W4313431348 created "2023-01-06" @default.
• W4313431348 creator A5011544360 @default.
• W4313431348 creator A5024586315 @default.
• W4313431348 creator A5054418515 @default.
• W4313431348 creator A5057292712 @default.
• W4313431348 creator A5076771868 @default.
• W4313431348 creator A5089981020 @default.
• W4313431348 date "2022-12-20" @default.
• W4313431348 modified "2023-09-25" @default.
• W4313431348 title "Study on the relationship between vitamin D level and macrophage typing in patients with type 2 diabetes mellitus" @default.
• W4313431348 cites W1925325876 @default.
• W4313431348 cites W1976643033 @default.
• W4313431348 cites W1980376777 @default.
• W4313431348 cites W1981056356 @default.
• W4313431348 cites W2013090406 @default.
• W4313431348 cites W2013907053 @default.
• W4313431348 cites W2016591779 @default.
• W4313431348 cites W2020293276 @default.
• W4313431348 cites W2042207589 @default.
• W4313431348 cites W2062361583 @default.
• W4313431348 cites W2081810806 @default.
• W4313431348 cites W2153059487 @default.
• W4313431348 cites W2170621724 @default.
• W4313431348 cites W2519232670 @default.
• W4313431348 cites W2560633563 @default.
• W4313431348 cites W2590158027 @default.
• W4313431348 cites W2606123402 @default.
• W4313431348 cites W2606344374 @default.
• W4313431348 cites W2767377810 @default.
• W4313431348 cites W2795130010 @default.
• W4313431348 cites W2807282451 @default.
• W4313431348 cites W2887589427 @default.
• W4313431348 cites W2907021984 @default.
• W4313431348 cites W2915377991 @default.
• W4313431348 cites W2922072814 @default.
• W4313431348 cites W2923043741 @default.
• W4313431348 cites W2931886845 @default.
• W4313431348 cites W2944962721 @default.
• W4313431348 cites W2945456735 @default.
• W4313431348 cites W2948260140 @default.
• W4313431348 cites W2953512802 @default.
• W4313431348 cites W2973119673 @default.
• W4313431348 cites W3080909861 @default.
• W4313431348 doi "https://doi.org/10.1007/s13410-022-01150-8" @default.
• W4313431348 hasPublicationYear "2022" @default.
• W4313431348 type Work @default.
• W4313431348 citedByCount "0" @default.
• W4313431348 crossrefType "journal-article" @default.
• W4313431348 hasAuthorship W4313431348A5011544360 @default.
• W4313431348 hasAuthorship W4313431348A5024586315 @default.
• W4313431348 hasAuthorship W4313431348A5054418515 @default.
• W4313431348 hasAuthorship W4313431348A5057292712 @default.
• W4313431348 hasAuthorship W4313431348A5076771868 @default.
• W4313431348 hasAuthorship W4313431348A5089981020 @default.
• W4313431348 hasBestOaLocation W43134313481 @default.
• W4313431348 hasConcept C124490489 @default.
• W4313431348 hasConcept C126322002 @default.
• W4313431348 hasConcept C134018914 @default.
• W4313431348 hasConcept C137061746 @default.
• W4313431348 hasConcept C202751555 @default.
• W4313431348 hasConcept C203014093 @default.
• W4313431348 hasConcept C2776682551 @default.
• W4313431348 hasConcept C2777180221 @default.
• W4313431348 hasConcept C2779244956 @default.
• W4313431348 hasConcept C2908647359 @default.
• W4313431348 hasConcept C2910068830 @default.
• W4313431348 hasConcept C2910375186 @default.
• W4313431348 hasConcept C553184892 @default.
• W4313431348 hasConcept C55493867 @default.
• W4313431348 hasConcept C555293320 @default.
• W4313431348 hasConcept C71924100 @default.
• W4313431348 hasConcept C86803240 @default.
• W4313431348 hasConcept C99454951 @default.
• W4313431348 hasConceptScore W4313431348C124490489 @default.
• W4313431348 hasConceptScore W4313431348C126322002 @default.
• W4313431348 hasConceptScore W4313431348C134018914 @default.
• W4313431348 hasConceptScore W4313431348C137061746 @default.
• W4313431348 hasConceptScore W4313431348C202751555 @default.
• W4313431348 hasConceptScore W4313431348C203014093 @default.
• W4313431348 hasConceptScore W4313431348C2776682551 @default.
• W4313431348 hasConceptScore W4313431348C2777180221 @default.
• W4313431348 hasConceptScore W4313431348C2779244956 @default.
• W4313431348 hasConceptScore W4313431348C2908647359 @default.
• W4313431348 hasConceptScore W4313431348C2910068830 @default.
• W4313431348 hasConceptScore W4313431348C2910375186 @default.
• W4313431348 hasConceptScore W4313431348C553184892 @default.
• W4313431348 hasConceptScore W4313431348C55493867 @default.
• W4313431348 hasConceptScore W4313431348C555293320 @default.
• W4313431348 hasConceptScore W4313431348C71924100 @default.
• W4313431348 hasConceptScore W4313431348C86803240 @default.
• W4313431348 hasConceptScore W4313431348C99454951 @default.
• W4313431348 hasLocation W43134313481 @default.
• W4313431348 hasOpenAccess W4313431348 @default.
• W4313431348 hasPrimaryLocation W43134313481 @default.
• W4313431348 hasRelatedWork W141873526 @default.
• W4313431348 hasRelatedWork W2071103727 @default.
• W4313431348 hasRelatedWork W2127396703 @default.
• W4313431348 hasRelatedWork W2130345620 @default.
• W4313431348 hasRelatedWork W2141069430 @default.

• next