Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313431361> ?p ?o ?g. }
- W4313431361 endingPage "102387" @default.
- W4313431361 startingPage "102387" @default.
- W4313431361 abstract "Aging causes progressive deterioration of daily rhythms in behavioral and metabolic processes and disruption in the regular sleep-wake cycle. Circadian disruption is directly related to diverse age-induced health abnormalities. Rising evidence from various organisms shows that core clock gene mutations cause premature aging, reduced lifespan, and sleeping irregularities. Improving the clock functions and correcting its disruption by pharmacological interventions or time-regulated feeding patterns could be a novel avenue for effective clinical management of aging and sleep disorders. To this end, many drugs for sleep disorders and anti-aging compounds interact with the core clock machinery and alter the circadian output. Evaluation of dosing time-dependency and circadian regulation of drug metabolism for therapeutic improvement of the existing drugs is another fundamental facet of chronomedicine. Multiple studies have demonstrated dose-dependent manipulation of the circadian period and phase-shifting by pharmacologically active compounds. The chronobiology research field is gradually moving towards the development of novel therapeutic strategies based on targeting the molecular clock or dosing time-oriented medications. However, such translational research ventures would require more experimental evidence from studies on humans. This review discusses the impact of circadian rhythms on aging and sleep, emphasizing the potentiality of circadian medicine in aging attenuation and sleep disorders." @default.
- W4313431361 created "2023-01-06" @default.
- W4313431361 creator A5026814056 @default.
- W4313431361 creator A5044830014 @default.
- W4313431361 date "2023-01-01" @default.
- W4313431361 modified "2023-10-01" @default.
- W4313431361 title "Circadian medicine for aging attenuation and sleep disorders: Prospects and challenges" @default.
- W4313431361 cites W1645078148 @default.
- W4313431361 cites W1708864796 @default.
- W4313431361 cites W1841116434 @default.
- W4313431361 cites W1894310296 @default.
- W4313431361 cites W1932790829 @default.
- W4313431361 cites W1966711735 @default.
- W4313431361 cites W1967135663 @default.
- W4313431361 cites W1974047539 @default.
- W4313431361 cites W1974495707 @default.
- W4313431361 cites W1974854913 @default.
- W4313431361 cites W1975439065 @default.
- W4313431361 cites W1983157224 @default.
- W4313431361 cites W1986428317 @default.
- W4313431361 cites W1987699071 @default.
- W4313431361 cites W1991080086 @default.
- W4313431361 cites W19913304 @default.
- W4313431361 cites W1994994441 @default.
- W4313431361 cites W1995069275 @default.
- W4313431361 cites W1996172219 @default.
- W4313431361 cites W1998771362 @default.
- W4313431361 cites W2002304116 @default.
- W4313431361 cites W2003302378 @default.
- W4313431361 cites W2006068256 @default.
- W4313431361 cites W2007282158 @default.
- W4313431361 cites W2009665800 @default.
- W4313431361 cites W2010238890 @default.
- W4313431361 cites W2013198896 @default.
- W4313431361 cites W2015685907 @default.
- W4313431361 cites W2016539998 @default.
- W4313431361 cites W2023019692 @default.
- W4313431361 cites W2029785742 @default.
- W4313431361 cites W2032295697 @default.
- W4313431361 cites W2039466176 @default.
- W4313431361 cites W2039639342 @default.
- W4313431361 cites W2039931639 @default.
- W4313431361 cites W2048376025 @default.
- W4313431361 cites W2050467552 @default.
- W4313431361 cites W2051145352 @default.
- W4313431361 cites W2054503257 @default.
- W4313431361 cites W2061144372 @default.
- W4313431361 cites W2069822948 @default.
- W4313431361 cites W2075026875 @default.
- W4313431361 cites W2075565109 @default.
- W4313431361 cites W2080688864 @default.
- W4313431361 cites W2081094746 @default.
- W4313431361 cites W2081123610 @default.
- W4313431361 cites W2082825725 @default.
- W4313431361 cites W2085674106 @default.
- W4313431361 cites W2090026968 @default.
- W4313431361 cites W2094874423 @default.
- W4313431361 cites W2095836481 @default.
- W4313431361 cites W2097874062 @default.
- W4313431361 cites W2104310168 @default.
- W4313431361 cites W2108988707 @default.
- W4313431361 cites W2111322904 @default.
- W4313431361 cites W2115099692 @default.
- W4313431361 cites W2115218756 @default.
- W4313431361 cites W2115957809 @default.
- W4313431361 cites W2117375244 @default.
- W4313431361 cites W2120115128 @default.
- W4313431361 cites W2121847288 @default.
- W4313431361 cites W2122649002 @default.
- W4313431361 cites W2123319274 @default.
- W4313431361 cites W2130296687 @default.
- W4313431361 cites W2133918896 @default.
- W4313431361 cites W2138503496 @default.
- W4313431361 cites W2140204893 @default.
- W4313431361 cites W2140987470 @default.
- W4313431361 cites W2144280397 @default.
- W4313431361 cites W2146270980 @default.
- W4313431361 cites W2146586614 @default.
- W4313431361 cites W2147521321 @default.
- W4313431361 cites W2147712103 @default.
- W4313431361 cites W2151132444 @default.
- W4313431361 cites W2152075431 @default.
- W4313431361 cites W2154333461 @default.
- W4313431361 cites W2156113445 @default.
- W4313431361 cites W2163225965 @default.
- W4313431361 cites W2163920027 @default.
- W4313431361 cites W2164361361 @default.
- W4313431361 cites W2206206324 @default.
- W4313431361 cites W2254111343 @default.
- W4313431361 cites W2265054843 @default.
- W4313431361 cites W2292489640 @default.
- W4313431361 cites W2332108903 @default.
- W4313431361 cites W2403069611 @default.
- W4313431361 cites W2406604088 @default.
- W4313431361 cites W2489530548 @default.
- W4313431361 cites W2510560444 @default.
- W4313431361 cites W2560341155 @default.
- W4313431361 cites W2567503091 @default.