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• W4313431409 abstract "Since their clinical application in the1840s, the greatest mystery surrounding general anesthesia (GA) is how different kinds of general anesthetics cause reversible unconsciousness, and the precise neural mechanisms underlying the processes. Over past years, although many studies revealed the roles of cortex, thalamus, brainstem, especially the sleep-wake circuits in GA-induced loss of consciousness (LOC),the full picture of the neural circuit mechanism of GA is still largely unknown. Recent studies have focused on the importance of other brain regions. Here, we report that the activity of glutamatergic (Glu) neurons in the piriform cortex (PC), a critical brain region for odor encoding, began to increase during the LOC of GA and gradually recovered after recovery of consciousness. Chemical lesions of the anterior PC (APC) neurons accelerated the induction time of isoflurane anesthesia. Chemogenetic and optogenetic activation of APCGlu neurons prolonged isoflurane and sevoflurane anesthesia induction, whereas APCGlu neuron inhibition displayed the opposite effects. Moreover, the modification of APCGlu neurons did not affect the induction or emergence time of propofol GA. In addition, odor processing may be partially involved in the induction of isoflurane and sevoflurane GA regulated by APCGlu neurons. In conclusion, our findings reveal a critical role of APCGlu neurons in inhalational GA induction." @default.
• W4313431409 created "2023-01-06" @default.
• W4313431409 creator A5004392909 @default.
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• W4313431409 date "2023-01-01" @default.
• W4313431409 modified "2023-10-18" @default.
• W4313431409 title "Glutamatergic neurons of piriform cortex delay induction of inhalational general anesthesia" @default.
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• W4313431409 doi "https://doi.org/10.1016/j.fmre.2022.12.014" @default.
• W4313431409 hasPublicationYear "2023" @default.
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