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• W4313432592 abstract "ABSTRACT Experimental studies of microbial evolution have largely focused on monocultures of model organisms, but most microbes live in communities where interactions with other species may impact rates and modes of evolution. Using the cheese rind model microbial community, we determined how species interactions shape the evolution of the widespread food- and animal-associated bacterium Staphylococcus xylosus . We evolved S. xylosus for 450 generations alone or in co-culture with one of three microbes: the yeast Debaryomyces hansenii , the bacterium Brevibacterium aurantiacum , and the mold Penicillium solitum . We used the frequency of colony morphology mutants (pigment and colony texture phenotypes) and whole-genome sequencing of isolates to quantify phenotypic and genomic evolution after 15 weeks of the evolution. The yeast D. hansenii strongly promoted diversification of S. xylosus ; by the end of the experiment, all populations co-cultured with the yeast were dominated by pigment and colony morphology mutant phenotypes. Populations of S. xylosus grown alone, with Brevibacterium , or with Penicillium did not evolve novel phenotypic diversity. Whole-genome sequencing of individual mutant isolates across all four treatments revealed numerous unique mutations in the operons for the SigB, Agr, and WalKR global regulators, but only in the D. hansenii treatment. Phenotyping and RNA-seq experiments demonstrated that these mutations altered pigment and biofilm production, spreading, stress tolerance, and metabolism of S. xylosus . Fitness experiments revealed trade-offs of these mutations across biotic environments caused by antagonistic pleiotropy, where beneficial mutations that evolved in the presence of the yeast Debaryomyces had strong negative fitness effects in other biotic environments. IMPORTANCE Substantial phenotypic and genomic variation exists within microbial species, but the ecological factors that shape this strain diversity are poorly characterized. We demonstrate that the biotic context of a widespread Staphylococcus species can impact the evolution of strain diversity. This work demonstrates the potential for microbes in food production environments to rapidly evolve to novel substrates and biotic environments. Our findings may also help understand how other Staphylococcus species may evolve in multispecies microbiomes." @default.
• W4313432592 created "2023-01-06" @default.
• W4313432592 creator A5007999872 @default.
• W4313432592 creator A5014283964 @default.
• W4313432592 creator A5045556090 @default.
• W4313432592 creator A5049343301 @default.
• W4313432592 creator A5064858642 @default.
• W4313432592 creator A5068836501 @default.
• W4313432592 date "2022-12-19" @default.
• W4313432592 modified "2023-09-27" @default.
• W4313432592 title "Species interactions promote parallel evolution of global transcriptional regulators in a widespread<i>Staphylococcus</i>species" @default.
• W4313432592 cites W1144322538 @default.
• W4313432592 cites W1957752345 @default.
• W4313432592 cites W1963965900 @default.
• W4313432592 cites W1973608525 @default.
• W4313432592 cites W1974954111 @default.
• W4313432592 cites W1977370272 @default.
• W4313432592 cites W1980386768 @default.
• W4313432592 cites W1982565019 @default.
• W4313432592 cites W1983476402 @default.
• W4313432592 cites W1984605399 @default.
• W4313432592 cites W1990950816 @default.
• W4313432592 cites W2000063205 @default.
• W4313432592 cites W2009154274 @default.
• W4313432592 cites W2011208940 @default.
• W4313432592 cites W2012508946 @default.
• W4313432592 cites W2015624443 @default.
• W4313432592 cites W2020622205 @default.
• W4313432592 cites W2024775172 @default.
• W4313432592 cites W2038265036 @default.
• W4313432592 cites W2039813252 @default.
• W4313432592 cites W2040539560 @default.
• W4313432592 cites W2042023734 @default.
• W4313432592 cites W2046739987 @default.
• W4313432592 cites W2053564897 @default.
• W4313432592 cites W2064335586 @default.
• W4313432592 cites W2067039644 @default.
• W4313432592 cites W2068273643 @default.
• W4313432592 cites W2069330027 @default.
• W4313432592 cites W2073525898 @default.
• W4313432592 cites W2075396966 @default.
• W4313432592 cites W2086655099 @default.
• W4313432592 cites W2086867029 @default.
• W4313432592 cites W2096788764 @default.
• W4313432592 cites W2108744754 @default.
• W4313432592 cites W2111326608 @default.
• W4313432592 cites W2112945902 @default.
• W4313432592 cites W2118291047 @default.
• W4313432592 cites W2119534042 @default.
• W4313432592 cites W2120735676 @default.
• W4313432592 cites W2122792108 @default.
• W4313432592 cites W2129554829 @default.
• W4313432592 cites W2130143969 @default.
• W4313432592 cites W2135918794 @default.
• W4313432592 cites W2137028674 @default.
• W4313432592 cites W2144181899 @default.
• W4313432592 cites W2146796764 @default.
• W4313432592 cites W2149886824 @default.
• W4313432592 cites W2156414674 @default.
• W4313432592 cites W2162806329 @default.
• W4313432592 cites W2165749265 @default.
• W4313432592 cites W2166532908 @default.
• W4313432592 cites W2170551349 @default.
• W4313432592 cites W2301270613 @default.
• W4313432592 cites W2312516242 @default.
• W4313432592 cites W2397584302 @default.
• W4313432592 cites W2471370751 @default.
• W4313432592 cites W2480010979 @default.
• W4313432592 cites W2508506323 @default.
• W4313432592 cites W2518862890 @default.
• W4313432592 cites W2522753993 @default.
• W4313432592 cites W2616082873 @default.
• W4313432592 cites W2757191651 @default.
• W4313432592 cites W2767925490 @default.
• W4313432592 cites W2786739377 @default.
• W4313432592 cites W2792063834 @default.
• W4313432592 cites W2795173188 @default.
• W4313432592 cites W2800160465 @default.
• W4313432592 cites W2801802352 @default.
• W4313432592 cites W2883556263 @default.
• W4313432592 cites W2892537755 @default.
• W4313432592 cites W2942457686 @default.
• W4313432592 cites W2944951203 @default.
• W4313432592 cites W2946319157 @default.
• W4313432592 cites W2951033555 @default.
• W4313432592 cites W2952886087 @default.
• W4313432592 cites W2959195914 @default.
• W4313432592 cites W2973730666 @default.
• W4313432592 cites W2980529908 @default.
• W4313432592 cites W3004587631 @default.
• W4313432592 cites W3005473190 @default.
• W4313432592 cites W3034087136 @default.
• W4313432592 cites W3034447411 @default.
• W4313432592 cites W3038513832 @default.
• W4313432592 cites W3082140264 @default.
• W4313432592 cites W3102536671 @default.
• W4313432592 cites W3164271582 @default.
• W4313432592 cites W3179699745 @default.
• W4313432592 cites W3207988922 @default.
• W4313432592 cites W3214945847 @default.

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