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• W4313432846 abstract "Abstract Background : Colorectal cancer (CRC) is one of the most common cancers and is associated with high incidence and mortality rates around the world. It has brought tremendous losses to human health and wealth. Young adults are experiencing a rise in the incidence and mortality of colorectal carcinoma. Early detection and prevention of cancer are made possible through screening. At present, the faecal immunochemical test (FIT) is a noninvasive method that can be used for large-scale clinical screening of CRC status. Therefore, this study, based on colorectal cancer screening results in Tianjin from 2012 to 2020, was conducted to analyse the major differences in diagnostic performance parameters according to sex and age. Methods : This study was based on 89652 colonoscopies performed in the Tianjin CRC screening program from 2012 to 2020. Of these, 39991 had complete FIT and colonoscopy results. The differences in FIT results were analysed by sex and age. Results : According to this study, males were generally more likely to develop CRC than females, and the prevalence increased with age. FIT-negative males were more likely to have advanced colorectal neoplasms than females with positive results. The accuracy of detecting advanced colorectal cancer (AN )by FIT in each age group was 54.9%, 45.4%, 48.6%, and 49.5% in the 40-49, 50-59, 60-69, and ≥70 age groups, respectively. Conclusions: The accuracy of the FIT was the highest in the 40-49-year-old age group. Our research can provide guidance to formulate CRC screening strategies." @default.
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• W4313432846 date "2023-01-02" @default.
• W4313432846 modified "2023-09-27" @default.
• W4313432846 title "Diagnostic accuracy of the faecal immunochemical test highest in the 40–49 age group" @default.
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• W4313432846 doi "https://doi.org/10.21203/rs.3.rs-2397830/v1" @default.
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