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- W4313432913 endingPage "794" @default.
- W4313432913 startingPage "794" @default.
- W4313432913 abstract "Chromothripsis defines a genetic phenomenon where up to hundreds of clustered chromosomal rearrangements can arise in a single catastrophic event. The phenomenon is associated with cancer and congenital diseases. Most current models on the origin of chromothripsis suggest that prior to chromatin reshuffling numerous DNA double-strand breaks (DSBs) have to exist, i.e., chromosomal shattering precedes rearrangements. However, the preference of a DNA end to rearrange in a proximal accessible region led us to propose chromothripsis as the reaction product of successive chromatin rearrangements. We previously coined this process Alternative End Generation (AEG), where a single DSB with a repair-blocking end initiates a domino effect of rearrangements. Accordingly, chromothripsis is the end product of this domino reaction taking place in a single catastrophic event." @default.
- W4313432913 created "2023-01-06" @default.
- W4313432913 creator A5052110904 @default.
- W4313432913 creator A5058883430 @default.
- W4313432913 creator A5065616924 @default.
- W4313432913 creator A5075372474 @default.
- W4313432913 date "2023-01-02" @default.
- W4313432913 modified "2023-10-01" @default.
- W4313432913 title "Chromosomal Rearrangements and Chromothripsis: The Alternative End Generation Model" @default.
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