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• W4313437583 abstract "The role of sodium-glucose cotransporter 2 inhibitors (SLTG2i), developed initially as glucose-lowering agents, has represented a novelty in patients with heart failure (HF) and reduced ejection fraction (HFrEF) since dapagliflozin (DAPA-HF study) and empagliflozin (EMPEROR-Reduced study) were able to reduce morbidity and mortality in this setting regardless of the presence or absence of diabetes. In previous large clinical trials (EMPA-REG OUTCOME study, CANVAS, DECLARE-TIMI 58), SGLT2i have been shown to attenuate HF progression expressed by reducing the risk of HF hospitalizations in patients with type 2 diabetes mellitus mostly without HF at baseline. This benefit was then corroborated with positive results in HF outcomes (cardiovascular mortality and HF hospitalizations) in patients with HF with preserved ejection fraction (HFpEF) in the EMPEROR-Preserved (empagliflozin) and DELIVER (dapagliflozin) trials. Several biological mechanisms apart from the glycosuria are attributed to these agents in this last context, including anti-inflammatory effects, reduction of fibrosis and apoptosis, improvement of myocardial metabolism, mitochondrial function optimization, and oxidative stress protection. Moreover, SGLT2i can also improve ventricular loading conditions by forcing diuresis and natriuresis, and by enhancing vascular and renal function. In addition, SGLT2i can reduce myocardial passive stiffness (diastolic function) by enforcing the phosphorylation of myofilament modulatory proteins. This article provided an overview of the main pathophysiological characteristics of HFpEF and of the diverse mechanisms of action of SGLT2i in this setting. The supporting clinical evidence of SGLT2i in HFpEF (EMPEROR-Preserved and DELIVER trials) is also reviewed. This article is part of the Emerging concepts in heart failure management and treatment Special Issue: https://www.drugsincontext.com/special_issues/emerging-concepts-in-heart-failure-management-and-treatment." @default.
• W4313437583 created "2023-01-06" @default.
• W4313437583 creator A5009793787 @default.
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• W4313437583 date "2023-01-04" @default.
• W4313437583 modified "2023-10-17" @default.
• W4313437583 title "Emerging concepts in heart failure treatment and management: focus on SGLT2 inhibitors in heart failure with preserved ejection fraction" @default.
• W4313437583 cites W164205712 @default.
• W4313437583 cites W1926461615 @default.
• W4313437583 cites W1964152667 @default.
• W4313437583 cites W1966518108 @default.
• W4313437583 cites W2011130900 @default.
• W4313437583 cites W2035500729 @default.
• W4313437583 cites W2081262717 @default.
• W4313437583 cites W2098267336 @default.
• W4313437583 cites W2121747051 @default.
• W4313437583 cites W2136503478 @default.
• W4313437583 cites W2138173733 @default.
• W4313437583 cites W2140058582 @default.
• W4313437583 cites W2146264128 @default.
• W4313437583 cites W2148328779 @default.
• W4313437583 cites W2151498231 @default.
• W4313437583 cites W2152072062 @default.
• W4313437583 cites W2160479864 @default.
• W4313437583 cites W2163146298 @default.
• W4313437583 cites W2166074631 @default.
• W4313437583 cites W2171795919 @default.
• W4313437583 cites W2187526770 @default.
• W4313437583 cites W2273304042 @default.
• W4313437583 cites W2340916682 @default.
• W4313437583 cites W2460078740 @default.
• W4313437583 cites W2535547710 @default.
• W4313437583 cites W2553261268 @default.
• W4313437583 cites W2572657306 @default.
• W4313437583 cites W2582603147 @default.
• W4313437583 cites W2600611552 @default.
• W4313437583 cites W2752162750 @default.
• W4313437583 cites W2759147159 @default.
• W4313437583 cites W2763866789 @default.
• W4313437583 cites W2779679995 @default.
• W4313437583 cites W2790275265 @default.
• W4313437583 cites W2806857639 @default.
• W4313437583 cites W2887628755 @default.
• W4313437583 cites W2894953624 @default.
• W4313437583 cites W2897993744 @default.
• W4313437583 cites W2898602922 @default.
• W4313437583 cites W2900413769 @default.
• W4313437583 cites W2912993467 @default.
• W4313437583 cites W2913047767 @default.
• W4313437583 cites W2913394347 @default.
• W4313437583 cites W2914520547 @default.
• W4313437583 cites W2920243595 @default.
• W4313437583 cites W2936559636 @default.
• W4313437583 cites W2936593438 @default.
• W4313437583 cites W2944562662 @default.
• W4313437583 cites W2946084428 @default.
• W4313437583 cites W2947319348 @default.
• W4313437583 cites W2958997923 @default.
• W4313437583 cites W2971294569 @default.
• W4313437583 cites W2974260792 @default.
• W4313437583 cites W2989425857 @default.
• W4313437583 cites W3005251148 @default.
• W4313437583 cites W3012616651 @default.
• W4313437583 cites W3020088156 @default.
• W4313437583 cites W3022230909 @default.
• W4313437583 cites W3024144838 @default.
• W4313437583 cites W3037876601 @default.
• W4313437583 cites W3045013522 @default.
• W4313437583 cites W3081830235 @default.
• W4313437583 cites W3087152883 @default.
• W4313437583 cites W3101357080 @default.
• W4313437583 cites W3117018021 @default.
• W4313437583 cites W3127916746 @default.
• W4313437583 cites W3133511216 @default.
• W4313437583 cites W3146917213 @default.
• W4313437583 cites W3154796681 @default.
• W4313437583 cites W3164477560 @default.
• W4313437583 cites W3165051557 @default.
• W4313437583 cites W3184394733 @default.
• W4313437583 cites W3193297191 @default.
• W4313437583 cites W3193598686 @default.
• W4313437583 cites W3199343174 @default.
• W4313437583 cites W3205099776 @default.
• W4313437583 cites W3214295542 @default.
• W4313437583 cites W4207052998 @default.
• W4313437583 cites W4220742762 @default.
• W4313437583 cites W4220920855 @default.
• W4313437583 cites W4225976467 @default.
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• W4313437583 doi "https://doi.org/10.7573/dic.2022-7-1" @default.
• W4313437583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36660013" @default.
• W4313437583 hasPublicationYear "2023" @default.
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