Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313440157> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4313440157 endingPage "66" @default.
- W4313440157 startingPage "62" @default.
- W4313440157 abstract "Background: Benzodiazepines are regularly prescribed to treat patients in alcoholic withdrawal. After analyzing pharmacology of benzodiazepines, diazepam is faster metabolized and concentrated in the liver, as an active metabolite whereas lorazepam is metabolized in liver by conjugation and excreted in urine. lorazepam being a drug of choice used in patients with deranged liver functions is needed to be compared with that of diazepam. The objective of the study is the comparasion of two benzodiazepines in treatment of alcohol dependence syndrome in Nepal.
 Material and Methods: This was a prospective, open label study carried out in Department of Psychiatry, Nobel Medical College and Teaching Hospital, Biratnagar. 50 patients (25 in each) aged between 25 to 65 years diagnosed as alcohol dependent admitted and grouped in either diazepam or lorazepam alternatively. The doses prescribed to the diazepam group and lorazepam group are 30 mg/day and 8 mg/day respectively in divided doses. For both the treatment groups, the dose was tapered every alternate day for 10 days. The Clinical Institute Withdrawal Assessment Alcohol Scale Revised (CIWA-Ar) scale was used for withdrawal symptoms scoring on the baseline and day 10. Lab Investigations were performed but were not a part of the study.
 Results: Out of the Fifty patients included in the study, at day 0, the mean CIWA-Ar scores were similar in both the treatment groups: 24.38±5.03 in the diazepam group and 24.79±6.42 in the lorazepam group. There was a significant intragroup decrease in the CIWA-Ar scores measured from Day 0 to the end of 10 days (p<0.0001) in both treatment groups; there was no significant difference between the two groups
 Conclusion: Diazepam and lorazepam are equally effective in alcohol withdrawal detoxification." @default.
- W4313440157 created "2023-01-06" @default.
- W4313440157 creator A5000915560 @default.
- W4313440157 creator A5018748037 @default.
- W4313440157 creator A5048102731 @default.
- W4313440157 creator A5057176741 @default.
- W4313440157 date "2022-12-31" @default.
- W4313440157 modified "2023-09-26" @default.
- W4313440157 title "A Study on Comparison of Two Benzodiazepines in Treatment of Alcohol Dependence Syndrome in Nepal" @default.
- W4313440157 doi "https://doi.org/10.3126/jonmc.v11i2.50464" @default.
- W4313440157 hasPublicationYear "2022" @default.
- W4313440157 type Work @default.
- W4313440157 citedByCount "0" @default.
- W4313440157 crossrefType "journal-article" @default.
- W4313440157 hasAuthorship W4313440157A5000915560 @default.
- W4313440157 hasAuthorship W4313440157A5018748037 @default.
- W4313440157 hasAuthorship W4313440157A5048102731 @default.
- W4313440157 hasAuthorship W4313440157A5057176741 @default.
- W4313440157 hasBestOaLocation W43134401571 @default.
- W4313440157 hasConcept C126322002 @default.
- W4313440157 hasConcept C170493617 @default.
- W4313440157 hasConcept C185592680 @default.
- W4313440157 hasConcept C2776175493 @default.
- W4313440157 hasConcept C2776615572 @default.
- W4313440157 hasConcept C2777477808 @default.
- W4313440157 hasConcept C2778173252 @default.
- W4313440157 hasConcept C2779706987 @default.
- W4313440157 hasConcept C2780026642 @default.
- W4313440157 hasConcept C2780873584 @default.
- W4313440157 hasConcept C2781066024 @default.
- W4313440157 hasConcept C42219234 @default.
- W4313440157 hasConcept C55493867 @default.
- W4313440157 hasConcept C71924100 @default.
- W4313440157 hasConcept C98274493 @default.
- W4313440157 hasConceptScore W4313440157C126322002 @default.
- W4313440157 hasConceptScore W4313440157C170493617 @default.
- W4313440157 hasConceptScore W4313440157C185592680 @default.
- W4313440157 hasConceptScore W4313440157C2776175493 @default.
- W4313440157 hasConceptScore W4313440157C2776615572 @default.
- W4313440157 hasConceptScore W4313440157C2777477808 @default.
- W4313440157 hasConceptScore W4313440157C2778173252 @default.
- W4313440157 hasConceptScore W4313440157C2779706987 @default.
- W4313440157 hasConceptScore W4313440157C2780026642 @default.
- W4313440157 hasConceptScore W4313440157C2780873584 @default.
- W4313440157 hasConceptScore W4313440157C2781066024 @default.
- W4313440157 hasConceptScore W4313440157C42219234 @default.
- W4313440157 hasConceptScore W4313440157C55493867 @default.
- W4313440157 hasConceptScore W4313440157C71924100 @default.
- W4313440157 hasConceptScore W4313440157C98274493 @default.
- W4313440157 hasIssue "2" @default.
- W4313440157 hasLocation W43134401571 @default.
- W4313440157 hasOpenAccess W4313440157 @default.
- W4313440157 hasPrimaryLocation W43134401571 @default.
- W4313440157 hasRelatedWork W1757317506 @default.
- W4313440157 hasRelatedWork W1889369246 @default.
- W4313440157 hasRelatedWork W2035518733 @default.
- W4313440157 hasRelatedWork W2071688450 @default.
- W4313440157 hasRelatedWork W2076117152 @default.
- W4313440157 hasRelatedWork W2092652748 @default.
- W4313440157 hasRelatedWork W2137995812 @default.
- W4313440157 hasRelatedWork W2164021030 @default.
- W4313440157 hasRelatedWork W2197422277 @default.
- W4313440157 hasRelatedWork W2418899126 @default.
- W4313440157 hasVolume "11" @default.
- W4313440157 isParatext "false" @default.
- W4313440157 isRetracted "false" @default.
- W4313440157 workType "article" @default.