Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313440192> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4313440192 abstract "In this study, Syzygium polyanthum was standardized against gallic acid (GA), and a complete pharmacokinetic test was conducted using in vitro and in vivo models against this phytochemical. High-performance liquid chromatography showed that GA is a major phytochemical in aqueous extract of S. polyanthum. It exhibited a low equilibrium solubility and physiochemical stability at pH 2.0 and 7.4, but it deteriorated rapidly at pH 9.2. It showed low permeability toward Caco-2 intestinal absorption with eight times slower absorption in oral than intravenous administration. GA was unstable in mouse, rat, and dog plasma sera with in vitro half-lives (t1/2) of 60, 53, and 56 min, respectively, but was relatively stable in human plasma serum (t1/2 = 185 min). Approximately 5.6% of GA (10 µM) bound to the human plasma proteins. GA was stable in mouse, rat, dog, and human microsomal extracts with in vitro microsomal intrinsic clearance values of 72, 68, 6, and 22 µL/min/mg, respectively. GA selectively inhibited or stimulated the activity of the tested CYP450 enzymes. The in vivo oral bioavailability of GA was 54%, with short elimination half-life and a high volume of distribution. Thus, the mention pharmacokinetic features of GA must be considered during the development of GA-based products to yield the optimum dosage and pharmacological effect." @default.
- W4313440192 created "2023-01-06" @default.
- W4313440192 creator A5004662874 @default.
- W4313440192 creator A5005589266 @default.
- W4313440192 creator A5014894551 @default.
- W4313440192 creator A5024755335 @default.
- W4313440192 creator A5024898383 @default.
- W4313440192 creator A5050559547 @default.
- W4313440192 creator A5061749648 @default.
- W4313440192 creator A5075898757 @default.
- W4313440192 date "2022-12-20" @default.
- W4313440192 modified "2023-09-27" @default.
- W4313440192 title "Favourable drug-lead pharmacokinetic features for designing gallic acid-standardized Syzygium polyanthum aqueous extract-based product" @default.
- W4313440192 doi "https://doi.org/10.22146/ijp.3639" @default.
- W4313440192 hasPublicationYear "2022" @default.
- W4313440192 type Work @default.
- W4313440192 citedByCount "0" @default.
- W4313440192 crossrefType "journal-article" @default.
- W4313440192 hasAuthorship W4313440192A5004662874 @default.
- W4313440192 hasAuthorship W4313440192A5005589266 @default.
- W4313440192 hasAuthorship W4313440192A5014894551 @default.
- W4313440192 hasAuthorship W4313440192A5024755335 @default.
- W4313440192 hasAuthorship W4313440192A5024898383 @default.
- W4313440192 hasAuthorship W4313440192A5050559547 @default.
- W4313440192 hasAuthorship W4313440192A5061749648 @default.
- W4313440192 hasAuthorship W4313440192A5075898757 @default.
- W4313440192 hasBestOaLocation W43134401921 @default.
- W4313440192 hasConcept C112705442 @default.
- W4313440192 hasConcept C121332964 @default.
- W4313440192 hasConcept C125287762 @default.
- W4313440192 hasConcept C150903083 @default.
- W4313440192 hasConcept C155574463 @default.
- W4313440192 hasConcept C178790620 @default.
- W4313440192 hasConcept C181389837 @default.
- W4313440192 hasConcept C185592680 @default.
- W4313440192 hasConcept C195475562 @default.
- W4313440192 hasConcept C202751555 @default.
- W4313440192 hasConcept C207001950 @default.
- W4313440192 hasConcept C24890656 @default.
- W4313440192 hasConcept C2777056448 @default.
- W4313440192 hasConcept C2778004101 @default.
- W4313440192 hasConcept C2778362808 @default.
- W4313440192 hasConcept C43617362 @default.
- W4313440192 hasConcept C55493867 @default.
- W4313440192 hasConcept C71924100 @default.
- W4313440192 hasConcept C86803240 @default.
- W4313440192 hasConcept C87644729 @default.
- W4313440192 hasConcept C98274493 @default.
- W4313440192 hasConceptScore W4313440192C112705442 @default.
- W4313440192 hasConceptScore W4313440192C121332964 @default.
- W4313440192 hasConceptScore W4313440192C125287762 @default.
- W4313440192 hasConceptScore W4313440192C150903083 @default.
- W4313440192 hasConceptScore W4313440192C155574463 @default.
- W4313440192 hasConceptScore W4313440192C178790620 @default.
- W4313440192 hasConceptScore W4313440192C181389837 @default.
- W4313440192 hasConceptScore W4313440192C185592680 @default.
- W4313440192 hasConceptScore W4313440192C195475562 @default.
- W4313440192 hasConceptScore W4313440192C202751555 @default.
- W4313440192 hasConceptScore W4313440192C207001950 @default.
- W4313440192 hasConceptScore W4313440192C24890656 @default.
- W4313440192 hasConceptScore W4313440192C2777056448 @default.
- W4313440192 hasConceptScore W4313440192C2778004101 @default.
- W4313440192 hasConceptScore W4313440192C2778362808 @default.
- W4313440192 hasConceptScore W4313440192C43617362 @default.
- W4313440192 hasConceptScore W4313440192C55493867 @default.
- W4313440192 hasConceptScore W4313440192C71924100 @default.
- W4313440192 hasConceptScore W4313440192C86803240 @default.
- W4313440192 hasConceptScore W4313440192C87644729 @default.
- W4313440192 hasConceptScore W4313440192C98274493 @default.
- W4313440192 hasLocation W43134401921 @default.
- W4313440192 hasOpenAccess W4313440192 @default.
- W4313440192 hasPrimaryLocation W43134401921 @default.
- W4313440192 hasRelatedWork W1964074490 @default.
- W4313440192 hasRelatedWork W1970245702 @default.
- W4313440192 hasRelatedWork W1970331292 @default.
- W4313440192 hasRelatedWork W2001333918 @default.
- W4313440192 hasRelatedWork W2086460393 @default.
- W4313440192 hasRelatedWork W2314489661 @default.
- W4313440192 hasRelatedWork W2317627837 @default.
- W4313440192 hasRelatedWork W2379311614 @default.
- W4313440192 hasRelatedWork W2414263157 @default.
- W4313440192 hasRelatedWork W2753834235 @default.
- W4313440192 isParatext "false" @default.
- W4313440192 isRetracted "false" @default.
- W4313440192 workType "article" @default.