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- W4313441488 abstract "OBJECTIVE: Channa micropeltes extract contains albumin and omega-6 which possess antioxidant and anti-inflammatory agents that can promote macrophages in the wound healing process associated with diabetes mellitus (DM). In this study, we analyzed Nuclear Factor kappa B (NF-κB) and Vascular Endothelial Growth Factor (VEGF) expression as well as neovascular cells in the inflammatory stage of DM wound healing. METHODS: The 24 males Rattus novergicus were divided into 3 groups that were 20% Channa micropeltes ointment (Group I), 10% Channa striata extract ointment (Group II), and placebo ointment as a control (Group III). Ointments were applied 3 times daily. RESULTS: The highest expression of NF-κB was observed in Group III on Day 4 (15.50 ± 2.38), and the lowest was in treatment of Group I and Group II on Day 8 (4.75 ± 0.96). The highest expression of VEGF was observed in Group I on Day 8 (14.75 ± 0.96), and the lowest was Group III on Day 4 (7.00 ± 1.41). The highest count of neovascular cells was observed in Group I on Day 8 (11.00 ± 2.16), and the lowest was in Group III on Day 4 (5.50 ± 0.58). CONCLUSIONS: Channa micropeltes has an anti-inflammatory effect by regulating NF-κB expression and elevating VEGF expression in the angiogenesis process of DM wound healing." @default.
- W4313441488 created "2023-01-06" @default.
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- W4313441488 date "2022-12-07" @default.
- W4313441488 modified "2023-09-26" @default.
- W4313441488 title "Anti-Inflammatory Effect of<i> Channa micropeltes</i> Extract in Angiogenesis of Diabetes Mellitus Wound Healing" @default.
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- W4313441488 doi "https://doi.org/10.1900/rds.2022.18.166" @default.
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