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- W4313441876 abstract "This chapter focuses on human mast cells and basophils, because of their obvious relevance to human disease. Mast cells occupy sentinel positions in tissues where noxious substances might attempt entry and immediate-type hypersensitivity reactions typically begin. These cells are most concentrated at sites in the lamina propria around the upper and lower airways, conjunctiva, dermis, gastrointestinal mucosa, and perivascular tissues. Pharmacological responsiveness of mast cells also varies depending on the tissue source and differs from that of basophils. Cromolyn sodium (disodium cromoglycate) and nedocromil—each used for the treatment of allergic asthma, rhinitis, and conjunctivitis—at high concentrations are weak inhibitors of lung-derived mast cells, but not those from skin and intestine. The presence of highly sulfated proteoglycans in secretory granules of mast cells and basophils results in metachromasia when these cells are stained with basic dyes. Proteoglycans are composed of glycosaminoglycan side chains covalently linked to a single-chain protein core by a specific trisaccharide-protein linkage region." @default.
- W4313441876 created "2023-01-06" @default.
- W4313441876 creator A5053619303 @default.
- W4313441876 date "2023-01-03" @default.
- W4313441876 modified "2023-10-18" @default.
- W4313441876 title "Mast Cells and Basophils" @default.
- W4313441876 doi "https://doi.org/10.1201/9780429134432-4" @default.
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