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• W4313442628 abstract "Sesquiterpenes are modified triterpenes widely distributed in many plants and show potential biological activities. As part of an ongoing effort to search for comprehensive anti-HBV sesquiterpenes from herbs, herein we reported six new sesquiterpenes, saussunosids A-E (1, 3−6) and saussureamine F (2), as well as three known sesquiterpenoids (7−9) and one known acetylenic glucosides (10), from the roots of S. lappa collected in Lijiang county, Yunnan province, China. Saussunosids A-E (1, 3−6) were new sesquiterpene glycosides and saussureamine F (2) was a new amino acid–sesquiterpene conjugate. Their structures were determined by extensive analyses of NMR, HR-ESI-MS and acid hydrolysis. The absolute configuration of the new compounds (1−6) was established by coupling constants and ROESY correlations, as well as comparisons of the calculated ECD with the experimental ECD spectrum. Anti-hepatitis B virus (anti-HBV) activity evaluation suggested that compounds 2 and 7 showed inhibition of HBsAg with the value of 66.50% and 72.97%, respectively, while having no effects on HBeAg at 30 μM. Moreover, compounds 2 and 7 showed significant cytotoxicity with CC50 values of 14.85 ± 4.95 and 11.70 ± 2.04 μM against human hepatic cancer (HepG2), respectively." @default.
• W4313442628 created "2023-01-06" @default.
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• W4313442628 date "2023-02-01" @default.
• W4313442628 modified "2023-10-15" @default.
• W4313442628 title "New anti-HBV sesquiterpene glycosides and amino acid–sesquiterpene conjugates from the roots of Saussurea lappa" @default.
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• W4313442628 doi "https://doi.org/10.1016/j.phytol.2022.12.008" @default.
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