FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313442853> ?p ?o ?g. }

• W4313442853 endingPage "102982" @default.
• W4313442853 startingPage "102982" @default.
• W4313442853 abstract "Immune cell function is critically dependent on precise control over transcriptional output from the genome. In this respect, integration of environmental signals that regulate gene expression, specifically by transcription factors, enhancer DNA elements, genome topography and non-coding RNAs (ncRNAs), are key components. The first three have been extensively investigated. Even though non-coding RNAs represent the vast majority of cellular RNA species, this class of RNA remains historically understudied. This is partly because of a lag in technological and bioinformatic innovations specifically capable of identifying and accurately measuring their expression. Nevertheless, recent progress in this domain has enabled a profusion of publications identifying novel sub-types of ncRNAs and studies directly addressing the function of ncRNAs in human health and disease. Many ncRNAs, including circular and enhancer RNAs, have now been demonstrated to play key functions in the regulation of immune cells and to show associations with immune-mediated diseases. Some ncRNAs may function as biomarkers of disease, aiding in diagnostics and in estimating response to treatment, while others may play a direct role in the pathogenesis of disease. Importantly, some are relatively stable and are amenable to therapeutic targeting, for example through gene therapy. Here, we provide an overview of ncRNAs and review technological advances that enable their study and hold substantial promise for the future. We provide context-specific examples by examining the associations of ncRNAs with four prototypical human autoimmune diseases, specifically rheumatoid arthritis, psoriasis, inflammatory bowel disease and multiple sclerosis. We anticipate that the utility and mechanistic roles of these ncRNAs in autoimmunity will be further elucidated in the near future." @default.
• W4313442853 created "2023-01-06" @default.
• W4313442853 creator A5011934276 @default.
• W4313442853 creator A5017193457 @default.
• W4313442853 creator A5036588904 @default.
• W4313442853 creator A5077383811 @default.
• W4313442853 creator A5083746709 @default.
• W4313442853 date "2023-01-01" @default.
• W4313442853 modified "2023-10-05" @default.
• W4313442853 title "Non-coding RNAs in immunoregulation and autoimmunity: Technological advances and critical limitations" @default.
• W4313442853 cites W1521228688 @default.
• W4313442853 cites W1572643844 @default.
• W4313442853 cites W1597449789 @default.
• W4313442853 cites W1661896406 @default.
• W4313442853 cites W1666631946 @default.
• W4313442853 cites W1744683414 @default.
• W4313442853 cites W1898990505 @default.
• W4313442853 cites W1929978039 @default.
• W4313442853 cites W1965150798 @default.
• W4313442853 cites W1966054625 @default.
• W4313442853 cites W1969161156 @default.
• W4313442853 cites W1969631412 @default.
• W4313442853 cites W1976067040 @default.
• W4313442853 cites W1976367020 @default.
• W4313442853 cites W1978901723 @default.
• W4313442853 cites W1988085321 @default.
• W4313442853 cites W1994323880 @default.
• W4313442853 cites W1995177178 @default.
• W4313442853 cites W1995226230 @default.
• W4313442853 cites W1996193092 @default.
• W4313442853 cites W2005636452 @default.
• W4313442853 cites W2007844697 @default.
• W4313442853 cites W2010461414 @default.
• W4313442853 cites W2012825693 @default.
• W4313442853 cites W2014787267 @default.
• W4313442853 cites W2017919052 @default.
• W4313442853 cites W2018486357 @default.
• W4313442853 cites W2020441317 @default.
• W4313442853 cites W2023723781 @default.
• W4313442853 cites W2023869046 @default.
• W4313442853 cites W2024643935 @default.
• W4313442853 cites W2024716296 @default.
• W4313442853 cites W2026566929 @default.
• W4313442853 cites W2027010998 @default.
• W4313442853 cites W2031412765 @default.
• W4313442853 cites W2037120427 @default.
• W4313442853 cites W2037429489 @default.
• W4313442853 cites W2037505430 @default.
• W4313442853 cites W2042789810 @default.
• W4313442853 cites W2043250238 @default.
• W4313442853 cites W2043871178 @default.
• W4313442853 cites W2044758458 @default.
• W4313442853 cites W2044806644 @default.
• W4313442853 cites W2044833878 @default.
• W4313442853 cites W2045884210 @default.
• W4313442853 cites W2046359103 @default.
• W4313442853 cites W2049220563 @default.
• W4313442853 cites W2051943484 @default.
• W4313442853 cites W2052039819 @default.
• W4313442853 cites W2053293102 @default.
• W4313442853 cites W2058303505 @default.
• W4313442853 cites W2058585577 @default.
• W4313442853 cites W2059382687 @default.
• W4313442853 cites W2060678979 @default.
• W4313442853 cites W2061179865 @default.
• W4313442853 cites W2065124806 @default.
• W4313442853 cites W2068707459 @default.
• W4313442853 cites W2071271349 @default.
• W4313442853 cites W2073255550 @default.
• W4313442853 cites W2076825429 @default.
• W4313442853 cites W2080757130 @default.
• W4313442853 cites W2080977835 @default.
• W4313442853 cites W2082135842 @default.
• W4313442853 cites W2085364628 @default.
• W4313442853 cites W2092487710 @default.
• W4313442853 cites W2096010243 @default.
• W4313442853 cites W2096968558 @default.
• W4313442853 cites W2100218820 @default.
• W4313442853 cites W2100667488 @default.
• W4313442853 cites W2100966665 @default.
• W4313442853 cites W2102304447 @default.
• W4313442853 cites W2104806799 @default.
• W4313442853 cites W2105512929 @default.
• W4313442853 cites W2108421854 @default.
• W4313442853 cites W2111640815 @default.
• W4313442853 cites W2115996819 @default.
• W4313442853 cites W2116655875 @default.
• W4313442853 cites W2117165052 @default.
• W4313442853 cites W2117472344 @default.
• W4313442853 cites W2118182274 @default.
• W4313442853 cites W2119828270 @default.
• W4313442853 cites W2121352589 @default.
• W4313442853 cites W2125939011 @default.
• W4313442853 cites W2129304835 @default.
• W4313442853 cites W2129328414 @default.
• W4313442853 cites W2133090587 @default.
• W4313442853 cites W2133567825 @default.
• W4313442853 cites W2137034625 @default.

• next