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- W4313443024 endingPage "105384" @default.
- W4313443024 startingPage "105384" @default.
- W4313443024 abstract "Silymarin, a milk thistle extract, has anti-inflammatory, immunomodulatory, anti-lipid peroxidative, anti-fibrotic, anti-oxidative, and anti-proliferative properties. Silymarin exhibits not only anti-cancer functions through modulating various hallmarks of cancer, including cell cycle, metastasis, angiogenesis, apoptosis, and autophagy, by targeting a plethora of molecules, but also plays protective roles against chemotherapy-induced toxicity, such as nephrotoxicity, hepatotoxicity, cardiotoxicity, and neurotoxicity. One of the problems of silymarin in (pre)clinical studies is its poor water solubility, leading to low intestinal absorption and, therefore, low bioavailability. To address these challenges, silymarin nanoformulations have emerged with added benefits, including excellent drug loading, sustained release, improved cellular uptake, and targeting tumor cells. Besides the chemical and biological properties, here we summarized the anti-cancer functions and the mechanism of action of silymarin in both free form and nanoformulations and its protective roles against chemotherapy-induced toxicity." @default.
- W4313443024 created "2023-01-06" @default.
- W4313443024 creator A5002736746 @default.
- W4313443024 creator A5009121120 @default.
- W4313443024 creator A5025569254 @default.
- W4313443024 creator A5032386713 @default.
- W4313443024 creator A5083228843 @default.
- W4313443024 date "2023-01-01" @default.
- W4313443024 modified "2023-10-17" @default.
- W4313443024 title "Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations" @default.
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