FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313443418> ?p ?o ?g. }

• W4313443418 endingPage "102" @default.
• W4313443418 startingPage "89" @default.
• W4313443418 abstract "Renal tubular damage plays a key role in the pathogenesis of diabetic kidney disease (DKD), and one of the main pathological process associated with DKD in diabetic mice is the ferroptosis, a novel form of cell death caused by iron-dependent lipid peroxidation. Several researches suggested that empagliflozin may treat renal injury, but its effects on diabetic-related ferroptosis and underlying mechanisms were not fully elucidated. In this study, the influence of empagliflozin on renal injury was evaluated in vivo and in vitro in a mouse model and in high-glucose (HG) or Erastin-stimulated renal HK-2 cell line, respectively. Ferroptosis-related markers were assessed, including GSH, labile iron levels, and ferroptosis regulators by Western blot, qRT-PCR, immunohistochemistry, and immunofluorescence. The level of malondialdehyde (MDA) and the fluorescence intensity of BODIPY probe indicated the level of lipid peroxidation. It was demonstrated that solute carrier family 7, member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4) were less expressed in renal biopsy samples from patients affected by DKD than in those from non-diabetic renal disease patients (NDRD), proving the ferroptosis of tubular epithelial cells in case of DKD. Furthermore, empagliflozin markedly decreased the ferroptosis impairment in DKD mice, as well as in HG model of HK-2 cells. Our investigations showed the ability of empagliflozin to suppress ferroptosis was partially countered by AMP-activated protein kinase (AMPK) inhibitor, which led to a reduction of the nuclear translocation of the antioxidant transcription factor NFE2-related factor 2 (NRF2) and downregulation of target genes such as GPX4, ferritin heavy chain 1 (FTH1), and SLC7A11, while AMPK agonists were responsible for the enhancement of the protective effects of empagliflozin. Taken together, our findings showed that empagliflozin may prevent the development of ferroptosis by promoting the AMPK-mediated NRF2 activation pathway, providing important insights for possible novel treatment approaches for DKD." @default.
• W4313443418 created "2023-01-06" @default.
• W4313443418 creator A5013618345 @default.
• W4313443418 creator A5017941291 @default.
• W4313443418 creator A5023307306 @default.
• W4313443418 creator A5026100234 @default.
• W4313443418 creator A5026945054 @default.
• W4313443418 creator A5034667645 @default.
• W4313443418 creator A5052069858 @default.
• W4313443418 creator A5056051852 @default.
• W4313443418 creator A5081296680 @default.
• W4313443418 date "2023-02-01" @default.
• W4313443418 modified "2023-10-16" @default.
• W4313443418 title "Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK/NRF2 pathway" @default.
• W4313443418 cites W1969296748 @default.
• W4313443418 cites W1997183854 @default.
• W4313443418 cites W2056976690 @default.
• W4313443418 cites W2075089162 @default.
• W4313443418 cites W2076772241 @default.
• W4313443418 cites W2142693924 @default.
• W4313443418 cites W2152686807 @default.
• W4313443418 cites W2163294546 @default.
• W4313443418 cites W2167696180 @default.
• W4313443418 cites W2171642500 @default.
• W4313443418 cites W2273304042 @default.
• W4313443418 cites W2317521667 @default.
• W4313443418 cites W2500767839 @default.
• W4313443418 cites W2549188196 @default.
• W4313443418 cites W2550324626 @default.
• W4313443418 cites W2611610643 @default.
• W4313443418 cites W2653398740 @default.
• W4313443418 cites W2729021745 @default.
• W4313443418 cites W2753909435 @default.
• W4313443418 cites W2772844083 @default.
• W4313443418 cites W2777514005 @default.
• W4313443418 cites W2789304645 @default.
• W4313443418 cites W2795990765 @default.
• W4313443418 cites W2796837697 @default.
• W4313443418 cites W2890950654 @default.
• W4313443418 cites W2897993744 @default.
• W4313443418 cites W2909817598 @default.
• W4313443418 cites W2911720884 @default.
• W4313443418 cites W2916044705 @default.
• W4313443418 cites W2917798522 @default.
• W4313443418 cites W2954162996 @default.
• W4313443418 cites W2977026040 @default.
• W4313443418 cites W2999326578 @default.
• W4313443418 cites W3000523537 @default.
• W4313443418 cites W3005253578 @default.
• W4313443418 cites W3015312656 @default.
• W4313443418 cites W3033986070 @default.
• W4313443418 cites W3038036007 @default.
• W4313443418 cites W3047725065 @default.
• W4313443418 cites W3080857839 @default.
• W4313443418 cites W3087404124 @default.
• W4313443418 cites W3108493784 @default.
• W4313443418 cites W3118639203 @default.
• W4313443418 cites W3120318004 @default.
• W4313443418 cites W3129858746 @default.
• W4313443418 cites W3181498203 @default.
• W4313443418 cites W3201396612 @default.
• W4313443418 cites W3203592482 @default.
• W4313443418 cites W3204982646 @default.
• W4313443418 cites W3205560985 @default.
• W4313443418 cites W3212417317 @default.
• W4313443418 cites W3214441687 @default.
• W4313443418 cites W3216530989 @default.
• W4313443418 cites W4200273892 @default.
• W4313443418 cites W4205704013 @default.
• W4313443418 cites W4280632277 @default.
• W4313443418 cites W4281740042 @default.
• W4313443418 cites W4281980293 @default.
• W4313443418 cites W4283823052 @default.
• W4313443418 cites W4294992589 @default.
• W4313443418 doi "https://doi.org/10.1016/j.freeradbiomed.2022.12.088" @default.
• W4313443418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36581059" @default.
• W4313443418 hasPublicationYear "2023" @default.
• W4313443418 type Work @default.
• W4313443418 citedByCount "8" @default.
• W4313443418 countsByYear W43134434182023 @default.
• W4313443418 crossrefType "journal-article" @default.
• W4313443418 hasAuthorship W4313443418A5013618345 @default.
• W4313443418 hasAuthorship W4313443418A5017941291 @default.
• W4313443418 hasAuthorship W4313443418A5023307306 @default.
• W4313443418 hasAuthorship W4313443418A5026100234 @default.
• W4313443418 hasAuthorship W4313443418A5026945054 @default.
• W4313443418 hasAuthorship W4313443418A5034667645 @default.
• W4313443418 hasAuthorship W4313443418A5052069858 @default.
• W4313443418 hasAuthorship W4313443418A5056051852 @default.
• W4313443418 hasAuthorship W4313443418A5081296680 @default.
• W4313443418 hasConcept C126322002 @default.
• W4313443418 hasConcept C134018914 @default.
• W4313443418 hasConcept C158086472 @default.
• W4313443418 hasConcept C184235292 @default.
• W4313443418 hasConcept C185592680 @default.
• W4313443418 hasConcept C2775838275 @default.
• W4313443418 hasConcept C2775887513 @default.
• W4313443418 hasConcept C2776151105 @default.

• next