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- W4313443595 abstract "Bicuspid aortic valve (BAV) is a congenital condition with strong genetic determinants. It is well recognized that patients with BAV present with large annuluses however the prevalence is unclear, and the associated characteristics are unknown. The purpose of this study was to (1) assess the prevalence of large annulus in bicuspid aortic valve (BAV) patients and (2) provide phenotypic characterization of patients with BAV and large annulus. Using the echocardiography database of the University of Ottawa Heart Institute, we identified patients with BAV between 2015 and 2019. To compare the prevalence of enlarged annulus, patients with BAV were matched for age, sex, and body surface area (BSA) 1:1 with patients with tricuspid aortic valve identified from the same database. A large annulus was defined as a measured annulus above the 97.7% percentile of the predicted annulus size based on BSA calculated using the Leye formula (predicted annulus = 5.7*BSA + 12.1). We identified 567 adult patients with BAV. Prevalence of large annulus was 4 times higher in patients with BAV than TAV (22.4% vs. 5.2% respectively, P < 0.0001). After matching for age, gender, and BSA, BAV patients presented larger annulus size than TAV patients (23 mm vs. 21.4 mm respectively, P < 0.0001) and the prevalence of large annulus was less than 3 times higher (22.1% vs. 8.0% respectively, OR: 3.3 [2.2–4.9], P < 0.001). Compared to BAV patients with normal annulus size, BAV patients with large annulus were younger (45 ± 18 vs. 50 ± 18 years, P = 0.007), male sex (87% vs. 13%, P < 0.0001), presented with larger aortic root diameter (38.9 ± 5.5 vs. 34.9 ± 5.4 mm, P < 0.0001), larger ascending aorta diameter (38.2 ± 6.6 mm vs. 36.6 ± 6.5 mm, P = 0.02), lower aortic mean pressure gradient (13.3 ± 10.1 mmHg vs. 18.2 ± 16.1 mmHg, P < 0.0013), more frequently moderate or severe regurgitant (37.0% vs. 14.6%, P < 0.0001), and less frequently moderate or severe stenotic dysfunction (14.2% vs. 21.8%, P = 0.04). There was no significant difference in BSA (1.95 ± 0.23 vs. 1.95 ± 0.26 m2, P = 0.77). BAV patients presented more often with large annulus size than patients with TAV but the vast majority of BAV patients had normal annular dimensions. Patients with BAV and large annulus presented more frequently: as male, with larger aorta dimensions, and with more AR than AS. The genotypical subset of BAV patients with large annulus is still undetermined." @default.
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- W4313443595 date "2023-01-01" @default.
- W4313443595 modified "2023-09-26" @default.
- W4313443595 title "Prevalence and phenotypic characterization of patients with bicuspid aortic valve" @default.
- W4313443595 doi "https://doi.org/10.1016/j.acvdsp.2022.10.234" @default.
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