FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313443706> ?p ?o ?g. }

• W4313443706 endingPage "105511" @default.
• W4313443706 startingPage "105511" @default.
• W4313443706 abstract "Tick-borne encephalitis virus (TBEV) is a major cause of neurological infections in many regions of central, eastern and northern Europe and northern Asia. In approximately 15% of cases, TBEV infections lead to the development of severe encephalitis or meningitis. The main route of TBEV transmission is tick bites; however, ingestion of dairy products from infected animals (goats, cattle and sheep) is also a frequent cause of the disease. Therefore, vaccination of livestock in virus endemic regions could also contribute to the decrease in TBEV infection among humans. Although few vaccines against TBEV based on inactivated viruses are available for humans, due to high costs, vaccination is not mandatory in most of the affected countries. Moreover, there is still no vaccine for veterinary use. Here, we present a characterization and immunogenicity study of a new potential TBEV vaccine based on virus-like particles (VLPs) produced in Leishmania tarentolae cells. VLPs, which mimic native viral particles but do not contain genetic material, show good immunogenic potential. For the first time, we showed that the protozoan L. tarentolae expression system can be successfully used for the production of TBEV virus-like particles with highly efficient production. We confirmed that TBEV recombinant structural proteins (prM/M and E) from VLPs are highly recognized by neutralizing antibodies in in vitro analyses. Therefore, VLPs in combination with AddaVax adjuvant were used in immunization studies in a mouse model. VLPs proved to be highly immunogenic and induced the production of high levels of neutralizing antibodies. In a challenge experiment, immunization with VLPs provided full protection from lethal TBE in mice. Thus, we suggest that Leishmania-derived VLPs may be a good candidate for a safe alternative human vaccine with high efficiency of production. Moreover, this potential vaccine candidate may constitute a low-cost candidate for veterinary use." @default.
• W4313443706 created "2023-01-06" @default.
• W4313443706 creator A5000354728 @default.
• W4313443706 creator A5015674958 @default.
• W4313443706 creator A5030387144 @default.
• W4313443706 creator A5041236909 @default.
• W4313443706 creator A5078291340 @default.
• W4313443706 creator A5090806765 @default.
• W4313443706 creator A5091615531 @default.
• W4313443706 creator A5091771426 @default.
• W4313443706 date "2023-01-01" @default.
• W4313443706 modified "2023-10-05" @default.
• W4313443706 title "Functional characterization and immunogenicity of a novel vaccine candidate against tick-borne encephalitis virus based on Leishmania-derived virus-like particles" @default.
• W4313443706 cites W10605091 @default.
• W4313443706 cites W1530508050 @default.
• W4313443706 cites W1851383444 @default.
• W4313443706 cites W1985556288 @default.
• W4313443706 cites W1993272811 @default.
• W4313443706 cites W2013814519 @default.
• W4313443706 cites W2023545713 @default.
• W4313443706 cites W2029720028 @default.
• W4313443706 cites W2110156878 @default.
• W4313443706 cites W2110403693 @default.
• W4313443706 cites W2115962282 @default.
• W4313443706 cites W2117479892 @default.
• W4313443706 cites W2125944224 @default.
• W4313443706 cites W2132898662 @default.
• W4313443706 cites W2146700406 @default.
• W4313443706 cites W2154346335 @default.
• W4313443706 cites W2155924591 @default.
• W4313443706 cites W2173857061 @default.
• W4313443706 cites W2328041195 @default.
• W4313443706 cites W2338267612 @default.
• W4313443706 cites W2741681003 @default.
• W4313443706 cites W2767429166 @default.
• W4313443706 cites W2785543194 @default.
• W4313443706 cites W2798042901 @default.
• W4313443706 cites W2897720302 @default.
• W4313443706 cites W2914167396 @default.
• W4313443706 cites W2914477352 @default.
• W4313443706 cites W2971085884 @default.
• W4313443706 cites W3036734945 @default.
• W4313443706 cites W3103354612 @default.
• W4313443706 cites W340694999 @default.
• W4313443706 doi "https://doi.org/10.1016/j.antiviral.2022.105511" @default.
• W4313443706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36581050" @default.
• W4313443706 hasPublicationYear "2023" @default.
• W4313443706 type Work @default.
• W4313443706 citedByCount "4" @default.
• W4313443706 countsByYear W43134437062023 @default.
• W4313443706 crossrefType "journal-article" @default.
• W4313443706 hasAuthorship W4313443706A5000354728 @default.
• W4313443706 hasAuthorship W4313443706A5015674958 @default.
• W4313443706 hasAuthorship W4313443706A5030387144 @default.
• W4313443706 hasAuthorship W4313443706A5041236909 @default.
• W4313443706 hasAuthorship W4313443706A5078291340 @default.
• W4313443706 hasAuthorship W4313443706A5090806765 @default.
• W4313443706 hasAuthorship W4313443706A5091615531 @default.
• W4313443706 hasAuthorship W4313443706A5091771426 @default.
• W4313443706 hasBestOaLocation W43134437061 @default.
• W4313443706 hasConcept C104317684 @default.
• W4313443706 hasConcept C159047783 @default.
• W4313443706 hasConcept C159654299 @default.
• W4313443706 hasConcept C203014093 @default.
• W4313443706 hasConcept C22070199 @default.
• W4313443706 hasConcept C2522874641 @default.
• W4313443706 hasConcept C2776281056 @default.
• W4313443706 hasConcept C2776387124 @default.
• W4313443706 hasConcept C2776872762 @default.
• W4313443706 hasConcept C2777863537 @default.
• W4313443706 hasConcept C2779141303 @default.
• W4313443706 hasConcept C2779404267 @default.
• W4313443706 hasConcept C2780568436 @default.
• W4313443706 hasConcept C2780801004 @default.
• W4313443706 hasConcept C2780868878 @default.
• W4313443706 hasConcept C40767141 @default.
• W4313443706 hasConcept C55493867 @default.
• W4313443706 hasConcept C83455156 @default.
• W4313443706 hasConcept C86803240 @default.
• W4313443706 hasConceptScore W4313443706C104317684 @default.
• W4313443706 hasConceptScore W4313443706C159047783 @default.
• W4313443706 hasConceptScore W4313443706C159654299 @default.
• W4313443706 hasConceptScore W4313443706C203014093 @default.
• W4313443706 hasConceptScore W4313443706C22070199 @default.
• W4313443706 hasConceptScore W4313443706C2522874641 @default.
• W4313443706 hasConceptScore W4313443706C2776281056 @default.
• W4313443706 hasConceptScore W4313443706C2776387124 @default.
• W4313443706 hasConceptScore W4313443706C2776872762 @default.
• W4313443706 hasConceptScore W4313443706C2777863537 @default.
• W4313443706 hasConceptScore W4313443706C2779141303 @default.
• W4313443706 hasConceptScore W4313443706C2779404267 @default.
• W4313443706 hasConceptScore W4313443706C2780568436 @default.
• W4313443706 hasConceptScore W4313443706C2780801004 @default.
• W4313443706 hasConceptScore W4313443706C2780868878 @default.
• W4313443706 hasConceptScore W4313443706C40767141 @default.
• W4313443706 hasConceptScore W4313443706C55493867 @default.
• W4313443706 hasConceptScore W4313443706C83455156 @default.
• W4313443706 hasConceptScore W4313443706C86803240 @default.

• next