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- W4313443894 abstract "A series of novel trienomycin A (TA)-mimetic compounds (5a–p) have been designed, synthesized, and evaluated for their in vitro anti-neuroinflammatory and neuroprotective activities. Among them, compounds 5h, 5n, and 5o exhibits relatively strong NO inhibitory activity in LPS-activated BV-2 cells with the EC50 values of 12.4, 17.3, and 8.9 μM, respectively. Moreover, 5h showed evidently neuroprotective effect against H2O2-induced PC-12 cells without cytotoxicity at 20 μM. Overall, these compounds can provide a better understanding of the structure–activity relationship of TA and furnish research ideas for anti-neuroinflammatory and neuroprotective agents." @default.
- W4313443894 created "2023-01-06" @default.
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- W4313443894 date "2023-01-01" @default.
- W4313443894 modified "2023-09-30" @default.
- W4313443894 title "Trienomycin A-simplified analogs: Synthesis and anti-neuroinflammatory activity" @default.
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- W4313443894 doi "https://doi.org/10.1016/j.bmcl.2022.129122" @default.
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