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- W4313443904 abstract "Myocardial infarction (MI), stroke, peripheral arterial disease (PAD), heart failure (HF) and chronic kidney disease (CKD) are common cardiovascular renal disease (CVRD) complications for type 2 diabetes (T2D). However, for those with a single CVRD comorbidity, the incidence of a new CVRD complication and death is not well known. To assess the 5-year CVRD complication and mortality incidence for T2D patients with a single CVRD comorbidity or without CVRD at baseline. A cohort study of all T2D patients with a single CVRD or without CVRD (disease-free) at baseline (January 1st, 2014) identified and followed-up for 5 years within the French SNDS nationwide claims database. Incidence rates were estimated for 5 years and the risk of all-cause death was compared to the disease-free population using Cox proportional hazards risk model: hazard ratio (HR) with [95% confidence interval]. From about 2 million T2D patients without cancer or transplantation at baseline, 76.5% were disease-free, 7.9% with a single CVRD and the others having several CVRD comorbidities history. For the five-year CVRD complication and mortality incidence rates, CKD and HF were the most frequent (17.9 and 11.0 for 1000 patient-years (‰ PY), respectively) for the disease-free and all CVRD comorbid populations (ranging from 22.3‰ PY for the stroke population to 279.5‰ PY for HF + CKD population), far ahead of MI, stroke and PAD (from 3.9 to 35.2 ‰ PY), except PAD complication for PAD population (90.3‰ PY) and to a lesser degree stroke complication for stroke population (90.3‰ PY). The incidence rate of all-cause death was the highest for HF + CKD patients, followed by HF patients, then PAD, stroke and CKD patients (123.2, 72.3 and 48.3‰ PY, respectively). Compared to disease-free patients with same sex and age, the HR of death was 4.3 [4.2–4.5] higher for HF + CKD patients, 2.7 [2.7–2.8], 2.1 [2.0–2.1], 2.1 [2.0–2.1], 1.9 [1.9–1.9] and 1.4 [1.3–1.4] for HF, CKD, PAD, stroke and MI patients, respectively. While MI, stroke and PAD comorbidities remain major risks of complications for T2D patients, HF and CKD nowadays represent a clearly higher risk of CVRD complications and death, that needs improved preventive strategies." @default.
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- W4313443904 date "2023-01-01" @default.
- W4313443904 modified "2023-10-18" @default.
- W4313443904 title "Cardiovascular or renal disease (CVRD) complication and mortality incidence for type 2 diabetics with a single or without CVRD comorbidity: A 5-year SNDS nationwide claims database cohort study" @default.
- W4313443904 doi "https://doi.org/10.1016/j.acvdsp.2022.10.212" @default.
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