Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313443913> ?p ?o ?g. }
- W4313443913 endingPage "102597" @default.
- W4313443913 startingPage "102597" @default.
- W4313443913 abstract "Hyperuricemia is the increased serum uric acid concentration, associated with metabolic syndrome that commonly leads to heart disease, gout, and chronic nephropathy. In animals, uric acid can be oxidized by the uricase enzyme and excreted in the urine. Unfortunately, humans lack uricase. This study aimed to find uricase-producing probiotic lactobacilli. L. plantarum KU985438 and L. rhamnosus KU985439 were selected to produce functional fermented yogurts. Induced-hyperuricemic animal models were used to test the yogurts' hypouricemic, anti-inflammatory, and antioxidant effects. Male Wistar rats fed probiotics orally for seven days showed decreased levels of uric acid and ankle edema in the therapeutic and protective groups compared to the control (indomethacin-treated). The two yogurts also reduced TNF-α, IL-1β, and NF-kB concentrations in inflamed joints by decreasing oxidative stress. Histopathology showed arthritis rats with abnormalities, deformities, necrosis, and edema in their joints. In the protective group, the synovial membrane and articular surface were nearly normal with the administration of the two yogurts concurrently with hyperuricemia induction. In the therapeutic group, retrieval from hyperuricemia was observed after 7 days of probiotic administration. Immuno-staining of the reactive immune cells (iNOS) in arthritic rats showed high expression levels. Both conventional medicine and yogurts reduced immune-reactive cell activity in arthritis-affected rats. To the authors’ knowledge, this study is considered the first to explore the efficacy of lactobacilli on the reactive immune cell expression in arthritic rats. In conclusion, L. plantarum and L. rhamnosus, with potent therapeutic and protective efficacy against MSU-induced arthritis, could be used as functional food supplements." @default.
- W4313443913 created "2023-01-06" @default.
- W4313443913 creator A5015859329 @default.
- W4313443913 creator A5020144453 @default.
- W4313443913 creator A5037231386 @default.
- W4313443913 creator A5052021525 @default.
- W4313443913 creator A5053845812 @default.
- W4313443913 creator A5063464268 @default.
- W4313443913 date "2023-01-01" @default.
- W4313443913 modified "2023-09-26" @default.
- W4313443913 title "Hypouricemic, anti-inflammatory, and antioxidant activities of Lactobacillus-based functional yogurt in induced-arthritic male Wistar rats: Therapeutic and protective potentials" @default.
- W4313443913 cites W170430538 @default.
- W4313443913 cites W1775749144 @default.
- W4313443913 cites W1965171484 @default.
- W4313443913 cites W1969064923 @default.
- W4313443913 cites W1978397248 @default.
- W4313443913 cites W2003257415 @default.
- W4313443913 cites W2010446689 @default.
- W4313443913 cites W2012751072 @default.
- W4313443913 cites W2021235091 @default.
- W4313443913 cites W2037461711 @default.
- W4313443913 cites W2056434781 @default.
- W4313443913 cites W2062478417 @default.
- W4313443913 cites W2082219317 @default.
- W4313443913 cites W2099112053 @default.
- W4313443913 cites W2147543995 @default.
- W4313443913 cites W2149007754 @default.
- W4313443913 cites W2154084546 @default.
- W4313443913 cites W2197043200 @default.
- W4313443913 cites W2339446670 @default.
- W4313443913 cites W2498951363 @default.
- W4313443913 cites W2502606297 @default.
- W4313443913 cites W2624935343 @default.
- W4313443913 cites W2735151353 @default.
- W4313443913 cites W2737035290 @default.
- W4313443913 cites W2742729968 @default.
- W4313443913 cites W2767890877 @default.
- W4313443913 cites W2793071520 @default.
- W4313443913 cites W2901205834 @default.
- W4313443913 cites W2903993968 @default.
- W4313443913 cites W2921333758 @default.
- W4313443913 cites W2957833978 @default.
- W4313443913 cites W2969530594 @default.
- W4313443913 cites W2980357715 @default.
- W4313443913 cites W3001884228 @default.
- W4313443913 cites W3007446580 @default.
- W4313443913 cites W3089461142 @default.
- W4313443913 cites W3126126108 @default.
- W4313443913 cites W3155795064 @default.
- W4313443913 cites W3180841145 @default.
- W4313443913 cites W4205631817 @default.
- W4313443913 cites W4214729271 @default.
- W4313443913 cites W1599415614 @default.
- W4313443913 doi "https://doi.org/10.1016/j.bcab.2022.102597" @default.
- W4313443913 hasPublicationYear "2023" @default.
- W4313443913 type Work @default.
- W4313443913 citedByCount "0" @default.
- W4313443913 crossrefType "journal-article" @default.
- W4313443913 hasAuthorship W4313443913A5015859329 @default.
- W4313443913 hasAuthorship W4313443913A5020144453 @default.
- W4313443913 hasAuthorship W4313443913A5037231386 @default.
- W4313443913 hasAuthorship W4313443913A5052021525 @default.
- W4313443913 hasAuthorship W4313443913A5053845812 @default.
- W4313443913 hasAuthorship W4313443913A5063464268 @default.
- W4313443913 hasConcept C126322002 @default.
- W4313443913 hasConcept C185592680 @default.
- W4313443913 hasConcept C203014093 @default.
- W4313443913 hasConcept C2776151105 @default.
- W4313443913 hasConcept C2777077863 @default.
- W4313443913 hasConcept C2778004101 @default.
- W4313443913 hasConcept C2779721657 @default.
- W4313443913 hasConcept C2779881121 @default.
- W4313443913 hasConcept C2780255968 @default.
- W4313443913 hasConcept C2780261098 @default.
- W4313443913 hasConcept C2780402116 @default.
- W4313443913 hasConcept C523546767 @default.
- W4313443913 hasConcept C54355233 @default.
- W4313443913 hasConcept C55493867 @default.
- W4313443913 hasConcept C71924100 @default.
- W4313443913 hasConcept C86803240 @default.
- W4313443913 hasConcept C8891405 @default.
- W4313443913 hasConcept C98274493 @default.
- W4313443913 hasConceptScore W4313443913C126322002 @default.
- W4313443913 hasConceptScore W4313443913C185592680 @default.
- W4313443913 hasConceptScore W4313443913C203014093 @default.
- W4313443913 hasConceptScore W4313443913C2776151105 @default.
- W4313443913 hasConceptScore W4313443913C2777077863 @default.
- W4313443913 hasConceptScore W4313443913C2778004101 @default.
- W4313443913 hasConceptScore W4313443913C2779721657 @default.
- W4313443913 hasConceptScore W4313443913C2779881121 @default.
- W4313443913 hasConceptScore W4313443913C2780255968 @default.
- W4313443913 hasConceptScore W4313443913C2780261098 @default.
- W4313443913 hasConceptScore W4313443913C2780402116 @default.
- W4313443913 hasConceptScore W4313443913C523546767 @default.
- W4313443913 hasConceptScore W4313443913C54355233 @default.
- W4313443913 hasConceptScore W4313443913C55493867 @default.
- W4313443913 hasConceptScore W4313443913C71924100 @default.
- W4313443913 hasConceptScore W4313443913C86803240 @default.