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• W4313443957 abstract "The risk of aortic dissection during pregnancy remains poorly appreciated in women with BAV. To investigate aortic events associated with pregnancy in women with BAV and aortic dilatation and to estimate ascending aortic diameter at the time of pregnancy. We performed a retrospective study using data of women with BAV and aortic dilatation, not affected by a genetic syndrome and who have been pregnant, seen//treated in our center between 1996 and 2020. Assuming from the literature an annual aortic dilation rate of 0.2 mm at the sinuses of Valsalva and 0.4 mm at the tubular ascending aorta, we estimated ascending aortic diameters and Z-score at the time of pregnancy. We identified 47 women with BAV and aortic dilatation with an occurrence of 103 pregnancies. The median age at the time of pregnancy was 29 (26–33) years. No aortic dissection occurred during pregnancy or during the postpartum period. At distance of pregnancy and postpartum, acute aortic dissection occurred in 2 women and elective aortic surgery was performed on 8 women, associated with aortic valve replacement for 6 of them. The median age at first visit in our center was 43 (35–56) years old. Median largest ascending aortic diameter (root or tubular aorta) was 44 (40–47) mm corresponding to a median Z-score of 4.4 (3.6–5.1). At the time of pregnancy, the estimated median largest diameter of the ascending aorta was 37.2 (33.4–42.3) mm, and the estimated median Z-score was 3.4 (2.3–4.7). The largest aortic diameter was estimated to be ≥ 40 mm in 40/103 pregnancies, ≥ 45 mm in 15/103, and ≥ 50 mm in 0/103 (Fig. 1); Z-score was estimated to be ≥ 2 in 86/103 and ≥ 4 in 40/103 at the time of pregnancy. In our population of women with BAV and aortic dilatation, no aortic complication occurred during 103 pregnancies, even though, when estimating aortic diameter at the time of pregnancy, the rate of aortic dilation was high." @default.
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• W4313443957 date "2023-01-01" @default.
• W4313443957 modified "2023-09-27" @default.
• W4313443957 title "Aortic events during pregnancy in women with bicuspid aortic valve and aortic dilatation. A retrospective study" @default.
• W4313443957 doi "https://doi.org/10.1016/j.acvdsp.2022.10.143" @default.
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