FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313444041> ?p ?o ?g. }

• W4313444041 endingPage "102960" @default.
• W4313444041 startingPage "102960" @default.
• W4313444041 abstract "Nitrogen, a major element, is generally considered as one of the limiting factors for the growth of marine diatoms. Nitrogen availability influences not only nitrate assimilation but also urea cycle in diatoms, while the regulatory mechanism of nitrogen metabolism is still unknown. Nitrogen metabolite repression (NMR) is the most widely known regulatory circuit in fungal nitrogen metabolism, and NmrA is a negative regulator involved in NMR. We identified 6 putative NmrA encoding genes in Phaeodactylum tricornutum, a model pennate diatom, and phylogenetic analyses showed that the 6 NmrA isoforms were divided into three distinct evolutionary clades: bacterium (J37667, J46721), fungus (J31822) and animal (J50525, J45041 and J49854), reflecting the mosaic genome in diatoms which originated from secondary endosymbiotic event. Two highly transcriptionally nitrate-sensitive NmrA, J37667 (PtNmrA1) and J50525 (PtNmrA2), which both contained the characteristic nucleotide-binding glycine-rich motif and localized in cytoplasm and endoplasmic reticulum lumen respectively, were knockdown by RNA interference in P. tricornutum. Although the growth was not different, nitrate utilization was inhibited by PtNmrA knockdowns. Transcript levels of genes involved in transport and reduction of NO3− and NO2−, and in urea cycle were downregulated, while plastidial and mitochondrial GS/GOGAT, and enzymes related with the regeneration of ammonium and glutamate in mitochondria were strongly transcriptionally upregulated. The results suggested knockdown of NmrA decreased the nitrate utilization but enhanced mitochondrial nitrogen regeneration to satisfy nitrogen demands elsewhere in the cell, and PtNmrA might serve as a positive regulator of nitrate assimilation in the diatom." @default.
• W4313444041 created "2023-01-06" @default.
• W4313444041 creator A5016891766 @default.
• W4313444041 creator A5023595240 @default.
• W4313444041 creator A5030536674 @default.
• W4313444041 date "2023-01-01" @default.
• W4313444041 modified "2023-10-17" @default.
• W4313444041 title "NmrA acts as a positive regulator of nitrate assimilation in Phaeodactylum tricornutum" @default.
• W4313444041 cites W1602246888 @default.
• W4313444041 cites W1971385920 @default.
• W4313444041 cites W2000119789 @default.
• W4313444041 cites W2021361052 @default.
• W4313444041 cites W2027921745 @default.
• W4313444041 cites W2037045595 @default.
• W4313444041 cites W2038226984 @default.
• W4313444041 cites W2054798877 @default.
• W4313444041 cites W2068651431 @default.
• W4313444041 cites W2083773338 @default.
• W4313444041 cites W2099443615 @default.
• W4313444041 cites W2106814707 @default.
• W4313444041 cites W2108244474 @default.
• W4313444041 cites W2117363012 @default.
• W4313444041 cites W2128338576 @default.
• W4313444041 cites W2136406441 @default.
• W4313444041 cites W2136668140 @default.
• W4313444041 cites W2149495934 @default.
• W4313444041 cites W2152473128 @default.
• W4313444041 cites W2155563810 @default.
• W4313444041 cites W2167705142 @default.
• W4313444041 cites W2168120526 @default.
• W4313444041 cites W2282557535 @default.
• W4313444041 cites W2324710458 @default.
• W4313444041 cites W2564112444 @default.
• W4313444041 cites W2735277402 @default.
• W4313444041 cites W2741303371 @default.
• W4313444041 cites W2809911441 @default.
• W4313444041 cites W283858428 @default.
• W4313444041 cites W2977875097 @default.
• W4313444041 cites W3092725446 @default.
• W4313444041 cites W4200123583 @default.
• W4313444041 cites W4293222336 @default.
• W4313444041 cites W618528668 @default.
• W4313444041 cites W3212580615 @default.
• W4313444041 doi "https://doi.org/10.1016/j.algal.2022.102960" @default.
• W4313444041 hasPublicationYear "2023" @default.
• W4313444041 type Work @default.
• W4313444041 citedByCount "0" @default.
• W4313444041 crossrefType "journal-article" @default.
• W4313444041 hasAuthorship W4313444041A5016891766 @default.
• W4313444041 hasAuthorship W4313444041A5023595240 @default.
• W4313444041 hasAuthorship W4313444041A5030536674 @default.
• W4313444041 hasConcept C104317684 @default.
• W4313444041 hasConcept C165267168 @default.
• W4313444041 hasConcept C170493617 @default.
• W4313444041 hasConcept C178790620 @default.
• W4313444041 hasConcept C185592680 @default.
• W4313444041 hasConcept C18903297 @default.
• W4313444041 hasConcept C191771488 @default.
• W4313444041 hasConcept C2776384668 @default.
• W4313444041 hasConcept C2777202666 @default.
• W4313444041 hasConcept C2778902744 @default.
• W4313444041 hasConcept C2780655307 @default.
• W4313444041 hasConcept C3119751 @default.
• W4313444041 hasConcept C49045045 @default.
• W4313444041 hasConcept C537208039 @default.
• W4313444041 hasConcept C55493867 @default.
• W4313444041 hasConcept C59822182 @default.
• W4313444041 hasConcept C61174792 @default.
• W4313444041 hasConcept C62231903 @default.
• W4313444041 hasConcept C86803240 @default.
• W4313444041 hasConceptScore W4313444041C104317684 @default.
• W4313444041 hasConceptScore W4313444041C165267168 @default.
• W4313444041 hasConceptScore W4313444041C170493617 @default.
• W4313444041 hasConceptScore W4313444041C178790620 @default.
• W4313444041 hasConceptScore W4313444041C185592680 @default.
• W4313444041 hasConceptScore W4313444041C18903297 @default.
• W4313444041 hasConceptScore W4313444041C191771488 @default.
• W4313444041 hasConceptScore W4313444041C2776384668 @default.
• W4313444041 hasConceptScore W4313444041C2777202666 @default.
• W4313444041 hasConceptScore W4313444041C2778902744 @default.
• W4313444041 hasConceptScore W4313444041C2780655307 @default.
• W4313444041 hasConceptScore W4313444041C3119751 @default.
• W4313444041 hasConceptScore W4313444041C49045045 @default.
• W4313444041 hasConceptScore W4313444041C537208039 @default.
• W4313444041 hasConceptScore W4313444041C55493867 @default.
• W4313444041 hasConceptScore W4313444041C59822182 @default.
• W4313444041 hasConceptScore W4313444041C61174792 @default.
• W4313444041 hasConceptScore W4313444041C62231903 @default.
• W4313444041 hasConceptScore W4313444041C86803240 @default.
• W4313444041 hasFunder F4320321001 @default.
• W4313444041 hasFunder F4320321133 @default.
• W4313444041 hasLocation W43134440411 @default.
• W4313444041 hasOpenAccess W4313444041 @default.
• W4313444041 hasPrimaryLocation W43134440411 @default.
• W4313444041 hasRelatedWork W153215138 @default.
• W4313444041 hasRelatedWork W181057089 @default.
• W4313444041 hasRelatedWork W1964022353 @default.
• W4313444041 hasRelatedWork W2062877971 @default.

• next