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• W4313444430 endingPage "258" @default.
• W4313444430 startingPage "237" @default.
• W4313444430 abstract "Type 2 diabetesDiabetes mellitus is associated with a high risk of heart failureHeart failure, in part because of its potential to induce impaired cardiac function even in the absence of coronary artery disease and hypertensionHypertension. The pathogenesis of diabetic cardiomyopathyDiabetic cardiomyopathy is not yet fully understood, although it is known that alterations in the cardiac substrate metabolism and energy play a significant role in the development and progression of this condition. Among these abnormalities, increased fatty acid storage and utilization, associated with reduced glucose oxidation and altered mitochondrial oxidative phosphorylation stand out. One of the key connections linking diabetesDiabetes and the remarkably prevalence of cardiomyopathy is the renin angiotensin systemRenin angiotensin system (RAS) hyperactivation. RAS has been described for its crucial involvement in the generation and progression of diabetic cardiovascular complications, as its exacerbated activation supports mechanisms that lead to cardiomyocyteCardiomyocytes death and myocardial fibrosis. The importance of RAS blockage in the prevention of diabetic cardiomyopathyDiabetic cardiomyopathy exhibits the fundamental role that RASRenin angiotensin system plays in the onset and development of this pathology. Angiotensin-converting enzyme inhibitors and blockers of angiotensin IIAngiotensin II actions denote the first-line therapy for primary and secondary prevention of cardiovascular diseaseCardiovascular disease in type 2 diabetic. Recent studies have revealed new features of RASRenin angiotensin system and, consequently, new therapeutic potential against diabetic cardiomyopathyDiabetic cardiomyopathy. In this chapter, a description of the main mechanisms involved in the correlation between excessive activation of the RASRenin angiotensin system and type 2 diabetesDiabetes is presented, with attention on mechanisms associated to pathogenesis and progression of diabetic cardiomyopathyDiabetic cardiomyopathy." @default.
• W4313444430 created "2023-01-06" @default.
• W4313444430 creator A5028938548 @default.
• W4313444430 creator A5033901610 @default.
• W4313444430 creator A5039642613 @default.
• W4313444430 date "2023-01-01" @default.
• W4313444430 modified "2023-09-27" @default.
• W4313444430 title "Renin Angiotensin System in the Pathophysiology of Diabetic Cardiomyopathy in Type 2 Diabetes" @default.
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