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• W4313444495 abstract "This chapter presents the evaluation of the impact of nonsynonymous single nucleotide polymorphisms (nsSNPs) in the renin-angiotensin-aldosterone systemRenin-angiotensin-aldosterone system (RAAS) on patients’ phenotypes not only in regard to arterial hypertensionHypertension and its complications, but also in regard to other conditions from the fields of interest outside cardiovascular medicine. The impact of nsSNPs in panels for the genes of reninRenin, angiotensinogen, angiotensin-converting enzyme, angiotensin receptor and aldosteroneAldosterone synthase is presented here together with a clinical picture of the investigated cohorts and the impact of nsSNPs on peptide-protein interactions. The first figure in the chapter presents—in a simplified mode—the location of the described genes in the human karyogram, and the second one—the geographical distribution of the probands who participated in the studies described here. A synopsis of the clinical context of the investigated nsSNPs is presented in the table. GeneticGenetics variability in nsSNPs of the RAASRenin-angiotensin-aldosterone system is involved in the pathogenesis of arterial hypertensionHypertension and its complications, and surprisingly also in the pathogenesis of conditions not associated with elevated blood pressure, like neoplasms or inflammatory processes." @default.
• W4313444495 created "2023-01-06" @default.
• W4313444495 creator A5001929107 @default.
• W4313444495 date "2023-01-01" @default.
• W4313444495 modified "2023-10-18" @default.
• W4313444495 title "Genetic Polymorphisms in the Renin-Angiotensin-Aldosterone System" @default.
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• W4313444495 doi "https://doi.org/10.1007/978-3-031-14952-8_7" @default.
• W4313444495 hasPublicationYear "2023" @default.
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