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• W4313446033 abstract "The Renin angiotensin systemRenin angiotensin system (RAS) plays an essential role in regulating the angiotensin IIAngiotensin II levels in the body and maintaining cardiovascular homeostasis. However, overactivation of RAS leads to hypertensionHypertension and cardiac overload, especially in the left ventricleLeft ventricle, causing cardiac hypertrophyCardiac hypertrophy. As a compensatory mechanism, the heart muscles undergo myocardial hypertrophy to maintain the cardiovascular function. Progression of cardiac hypertrophyCardiac hypertrophy along with other factors leads to heart failureHeart failure. RASRenin angiotensin system mediated high blood pressure is one of the major risk factors that initiates pathological changes in the coronary blood vessels, sometimes resulting in heart attack and stroke. The results of preclinical and limited number of clinical studies demonstrated that quercetinQuercetin possesses cardioprotective effects to prevent hypertensionHypertension, cardiac hypertrophyCardiac hypertrophy, and heart failureHeart failure. The multiple benefits of quercetinQuercetin are attributed to ACE inhibition, strong antioxidant and anti-inflammation properties and protection of endothelial function which collectively prevent coronary heart diseaseCoronary heart disease, hypertensionHypertension, myocardial hypertrophy and heart failureHeart failure. This review aims to provide an overview of the current knowledge about the impact of RASRenin angiotensin system in causing CVDs, to highlight cellular and molecular mechanisms of quercetinQuercetin involved in ACE inhibition via RASRenin angiotensin system pathway and to slow down the progression of cardiac hypertrophyCardiac hypertrophy and heart failureHeart failure. Despite having an enormous therapeutic potential, the usefulness of quercetinQuercetin at present is limited due to its low aqueous solubility and oral bioavailability. Different formulations are being developed to enhance the bioavailability of quercetinQuercetin by employing novel drug delivery systems which will pave the ways for discovering cost-effective, affordable, and safe drugs for treating CVDs." @default.
• W4313446033 created "2023-01-06" @default.
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• W4313446033 date "2023-01-01" @default.
• W4313446033 modified "2023-10-18" @default.
• W4313446033 title "Quercetin: A Promising Flavonoid for the Therapy of Cardiac Hypertrophy and Heart Failure Mediated by the Renin Angiotensin System" @default.
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• W4313446033 doi "https://doi.org/10.1007/978-3-031-14952-8_23" @default.
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