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• W4313446089 abstract "The renin angiotensin systemRenin angiotensin system (RAS) is a hormonal system responsible for regulating blood pressure. Complex interplay of geneticsGenetics and environmental factors in developing hypertensionHypertension has attracted a lot of attention in recent years. Different approaches in geneticGenetics analysis has illustrated numerous geneticGenetics loci that contribute in hypertensionHypertension. Some missing parts of heritability in hypertensionHypertension might be explained by epigeneticEpigenetics changes. Expression of RASRenin angiotensin system genes changes due to alteration of DNA methylation. The consequence of this alteration could be the development of hypertensionHypertension. DNA methylation is not the only epigeneticEpigenetics change in the RAS system. Other epigeneticEpigenetics modifications in the RASRenin angiotensin system system include histone modifications, nucleosome positioning, transcriptional control with DNA-binding proteins and non-coding RNAs, and translational control with microRNAs and RNA-binding proteins. These changes might be able to change the RASRenin angiotensin system function. Understanding and monitoring these changes would lead to better understanding of changeable and/or reversible alteration that would be of great value in diagnostic and therapeutic approaches. BiosensorsBiosensor are potential tools to detect and monitor changes. In this chapter, the epigeneticEpigenetics changes as well as available biosensorsBiosensor will be discussed." @default.
• W4313446089 created "2023-01-06" @default.
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• W4313446089 date "2023-01-01" @default.
• W4313446089 modified "2023-10-18" @default.
• W4313446089 title "Epigenetics Changes in Renin Angiotensin System (RAS): Application of Biosensors for Monitoring These Changes" @default.
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• W4313446089 doi "https://doi.org/10.1007/978-3-031-14952-8_6" @default.
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