FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313446295> ?p ?o ?g. }

• W4313446295 abstract "Abstract The objective of our study was to investigate the impact of the mitochondrial polygenic score (MGS) and lifestyle/environmental data on age at onset in LRRK2 p.Gly2019Ser parkinsonism ( LRRK2 -PD) and idiopathic Parkinson’s disease (iPD). In this study, we included N=486 patients with LRRK2 -PD and N=9259 patients with iPD from AMP-PD, Fox Insight, and a Tunisian Arab-Berber founder population. Genotyping data was utilized to perform the MGS analysis, using 14 Single Nucleotide Polymorphisms (SNPs) from genes causally associated with mitochondrial function and PD risk. Additionally, lifestyle and environmental data were obtained from the PD risk factor questionnaire (PD-RFQ). Correlation analyses and linear regression models were used to assess the relationship between MGS, lifestyle/environment, and AAO. We observed that higher MGS was associated with earlier AAO in patients with LRRK2 -PD (p=4.0×10 −4 , β=-0.18) but not in patients with iPD. A correlation between MGS and AAO was visibly stronger in European ancestry LRRK2 -PD patients (p=0.01, r=-0.16) than in Tunisian Arab-Berber patients (p=0.44, r=-0.05). We found that the MGS interacted with coffee (p=0.03, β=-0.38) and caffeinated soda consumption (p=0.03, β=-0.37) in LRRK2 -PD and with caffeine soda consumption (p=0.047, β=-0.22) and pesticide exposure (p=0.02, β=-0.37) in iPD. Thus, patients with a high MGS had an earlier AAO only if they consumed caffeine or were exposed to pesticides. The MGS related to mitochondrial function was associated with AAO in LRRK2 -PD but not iPD with an ethnic-specific effect. Caffeine consumption or pesticide exposure interacted with MGS to predict PD AAO. Our study suggests gene-environment interactions as modifiers of AAO in LRRK2 -PD." @default.
• W4313446295 created "2023-01-06" @default.
• W4313446295 creator A5008185656 @default.
• W4313446295 creator A5020176695 @default.
• W4313446295 creator A5024773860 @default.
• W4313446295 creator A5027632970 @default.
• W4313446295 creator A5046153909 @default.
• W4313446295 creator A5048711837 @default.
• W4313446295 creator A5049446559 @default.
• W4313446295 creator A5055429770 @default.
• W4313446295 creator A5069738625 @default.
• W4313446295 creator A5080693143 @default.
• W4313446295 creator A5080861807 @default.
• W4313446295 creator A5087318432 @default.
• W4313446295 creator A5087351416 @default.
• W4313446295 creator A5088348981 @default.
• W4313446295 date "2023-01-03" @default.
• W4313446295 modified "2023-09-27" @default.
• W4313446295 title "Interaction of mitochondrial polygenic score and environmental factors in LRRK2 p.Gly2019Ser parkinsonism" @default.
• W4313446295 cites W1135627251 @default.
• W4313446295 cites W1977261578 @default.
• W4313446295 cites W1992436001 @default.
• W4313446295 cites W1993790483 @default.
• W4313446295 cites W2047145474 @default.
• W4313446295 cites W2092590432 @default.
• W4313446295 cites W2097427623 @default.
• W4313446295 cites W2098827841 @default.
• W4313446295 cites W2104549677 @default.
• W4313446295 cites W2115295034 @default.
• W4313446295 cites W2143906078 @default.
• W4313446295 cites W2161633633 @default.
• W4313446295 cites W2315712516 @default.
• W4313446295 cites W2510973425 @default.
• W4313446295 cites W2511515754 @default.
• W4313446295 cites W2525713139 @default.
• W4313446295 cites W2767019924 @default.
• W4313446295 cites W2892332054 @default.
• W4313446295 cites W2900711967 @default.
• W4313446295 cites W2932671560 @default.
• W4313446295 cites W2945170956 @default.
• W4313446295 cites W2945978665 @default.
• W4313446295 cites W2952013316 @default.
• W4313446295 cites W2963160524 @default.
• W4313446295 cites W2969952587 @default.
• W4313446295 cites W2986932567 @default.
• W4313446295 cites W3008374045 @default.
• W4313446295 cites W3016919771 @default.
• W4313446295 cites W3043447347 @default.
• W4313446295 cites W3080311637 @default.
• W4313446295 cites W3082158481 @default.
• W4313446295 cites W3087707970 @default.
• W4313446295 cites W3112561953 @default.
• W4313446295 cites W3157567544 @default.
• W4313446295 cites W3158274091 @default.
• W4313446295 cites W3216327528 @default.
• W4313446295 cites W3217278112 @default.
• W4313446295 cites W4214944742 @default.
• W4313446295 cites W4230063602 @default.
• W4313446295 cites W4254687493 @default.
• W4313446295 cites W4280517466 @default.
• W4313446295 cites W4282829641 @default.
• W4313446295 cites W4285677475 @default.
• W4313446295 cites W4288740317 @default.
• W4313446295 cites W4292641357 @default.
• W4313446295 cites W4293581901 @default.
• W4313446295 doi "https://doi.org/10.1101/2023.01.02.23284113" @default.
• W4313446295 hasPublicationYear "2023" @default.
• W4313446295 type Work @default.
• W4313446295 citedByCount "0" @default.
• W4313446295 crossrefType "posted-content" @default.
• W4313446295 hasAuthorship W4313446295A5008185656 @default.
• W4313446295 hasAuthorship W4313446295A5020176695 @default.
• W4313446295 hasAuthorship W4313446295A5024773860 @default.
• W4313446295 hasAuthorship W4313446295A5027632970 @default.
• W4313446295 hasAuthorship W4313446295A5046153909 @default.
• W4313446295 hasAuthorship W4313446295A5048711837 @default.
• W4313446295 hasAuthorship W4313446295A5049446559 @default.
• W4313446295 hasAuthorship W4313446295A5055429770 @default.
• W4313446295 hasAuthorship W4313446295A5069738625 @default.
• W4313446295 hasAuthorship W4313446295A5080693143 @default.
• W4313446295 hasAuthorship W4313446295A5080861807 @default.
• W4313446295 hasAuthorship W4313446295A5087318432 @default.
• W4313446295 hasAuthorship W4313446295A5087351416 @default.
• W4313446295 hasAuthorship W4313446295A5088348981 @default.
• W4313446295 hasBestOaLocation W43134462951 @default.
• W4313446295 hasConcept C104317684 @default.
• W4313446295 hasConcept C126322002 @default.
• W4313446295 hasConcept C135763542 @default.
• W4313446295 hasConcept C153209595 @default.
• W4313446295 hasConcept C2776525014 @default.
• W4313446295 hasConcept C2779134260 @default.
• W4313446295 hasConcept C2779734285 @default.
• W4313446295 hasConcept C2780427247 @default.
• W4313446295 hasConcept C31467283 @default.
• W4313446295 hasConcept C54355233 @default.
• W4313446295 hasConcept C71924100 @default.
• W4313446295 hasConcept C86803240 @default.
• W4313446295 hasConceptScore W4313446295C104317684 @default.
• W4313446295 hasConceptScore W4313446295C126322002 @default.
• W4313446295 hasConceptScore W4313446295C135763542 @default.

• next