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• W4313446302 abstract "Our increased understanding of how a cell's microenvironment influences its behavior has fueled an interest in three-dimensional (3D) cell cultures for drug discovery. Particularly, scaffold-based 3D cultures are expected to recapitulate in vivo tissue stiffness and extracellular matrix composition more accurately than standard two-dimensional (2D) monolayer cultures. Here we present a 3D hydrogel cell culture setup suitable for automated screening with standard high-throughput screening (HTS) liquid handling equipment commonly found in a drug discovery laboratory. Further, we describe the steps required to validate the assay system for compound screening." @default.
• W4313446302 created "2023-01-06" @default.
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• W4313446302 date "2023-01-01" @default.
• W4313446302 modified "2023-09-23" @default.
• W4313446302 title "3D Hydrogel Cultures for High-Throughput Drug Discovery" @default.
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• W4313446302 doi "https://doi.org/10.1007/978-1-0716-2914-7_22" @default.
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• W4313446302 hasPublicationYear "2023" @default.
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