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• W4313446528 abstract "Background Quantitative US (QUS) using radiofrequency data analysis has been recently introduced for noninvasive evaluation of hepatic steatosis. Deep learning algorithms may improve the diagnostic performance of QUS for hepatic steatosis. Purpose To evaluate a two-dimensional (2D) convolutional neural network (CNN) algorithm using QUS parametric maps and B-mode images for diagnosis of hepatic steatosis, with the MRI-derived proton density fat fraction (PDFF) as the reference standard, in patients with nonalcoholic fatty liver disease (NAFLD). Materials and Methods: Consecutive adult participants with suspected NAFLD were prospectively enrolled at a single academic medical center from July 2020 to June 2021. Using radiofrequency data analysis, two QUS parameters (tissue attenuation imaging [TAI] and tissue scatter-distribution imaging [TSI]) were measured. On B-mode images, hepatic steatosis was graded using visual scoring (none, mild, moderate, or severe). Using B-mode images and two QUS parametric maps (TAI and TSI) as input data, the algorithm estimated the US fat fraction (USFF) as a percentage. The correlation between the USFF and MRI PDFF was evaluated using the Pearson correlation coefficient. The diagnostic performance of the USFF for hepatic steatosis (MRI PDFF ≥5%) was evaluated using receiver operating characteristic curve analysis and compared with that of TAI, TSI, and visual scoring. Results Overall, 173 participants (mean age, 51 years ± 14 [SD]; 96 men) were included, with 126 (73%) having hepatic steatosis (MRI PDFF ≥5%). USFF correlated strongly with MRI PDFF (Pearson r = 0.86, 95% CI: 0.82, 0.90; P < .001). For diagnosing hepatic steatosis (MRI PDFF ≥5%), the USFF yielded an area under the receiver operating characteristic curve of 0.97 (95% CI: 0.93, 0.99), higher than those of TAI, TSI, and visual scoring (P = .015, .006, and < .001, respectively), with a sensitivity of 90% (95% CI: 84, 95 [114 of 126]) and a specificity of 91% (95% CI: 80, 98 [43 of 47]) at a cutoff value of 5.7%. Conclusion A deep learning algorithm using quantitative US parametric maps and B-mode images accurately estimated the hepatic fat fraction and diagnosed hepatic steatosis in participants with nonalcoholic fatty liver disease. ClinicalTrials.gov registration nos. NCT04462562, NCT04180631 © RSNA, 2023 Supplemental material is available for this article. See also the editorial by Sidhu and Fang in this issue." @default.
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• W4313446528 date "2023-04-01" @default.
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• W4313446528 title "Two-dimensional Convolutional Neural Network Using Quantitative US for Noninvasive Assessment of Hepatic Steatosis in NAFLD" @default.
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• W4313446528 doi "https://doi.org/10.1148/radiol.221510" @default.
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