Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313446715> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4313446715 endingPage "18" @default.
- W4313446715 startingPage "9" @default.
- W4313446715 abstract "Neuropathologic and motor features of Parkinson’s disease can be induced in rodents by the pesticide rotenone. In this study, we aimed to determine whether nitric oxide synthase inhibition by NG-nitro-L-arginine methyl ester (L-NAME) could prevent neurodegeneration and biochemical changes induced by rotenone in rat brain. For this purpose, rats received subcutaneous injections of rotenone (1.5 mg/kg) every other day for two consecutive weeks and were treated at the same time with L-NAME at doses of 10 or 20 mg/kg, intraperitoneally. Oxidative stress indictors, malondialdehyde, reduced glutathione, and nitric oxide as well as paraoxonase-1 (PON-1) activity in brain, and the concentration of the antiapoptotic protein B cell/lymphoma-2 (Bcl2) in striatum were determined. Motor strength and coordination was assessed using wire hanging and stair tests. Neuronal degeneration was evaluated using hematoxylin & eosin-stained brain sections. Results: L-NAME reduced, in a dose-dependent manner the increase in lipid peroxidation (malondialdehyde) and nitric oxide and restored reduced glutathione levels in brain of rotenone-treated rats. Additionally, L-NAME prevented the inhibition of paraoxonase-1 activity and the decrease in Bcl2 concentration induced by the pesticide. It also prevented motor impairments in a dose-dependent manner. Furthermore, L-NAME treatment ameliorated the neurodegenerative effects of rotenone, as shown by the decrease in degenerated neurons in striatum and cerebral cortex. The results of the present study suggest that rotenone mediates its neurotoxic effects, at least in part by nitric oxide-dependent mechanisms." @default.
- W4313446715 created "2023-01-06" @default.
- W4313446715 creator A5028689490 @default.
- W4313446715 creator A5074160465 @default.
- W4313446715 creator A5075246930 @default.
- W4313446715 date "2022-07-06" @default.
- W4313446715 modified "2023-09-24" @default.
- W4313446715 title "Nitric Oxide Synthase Inhibition Protects Against RotenoneInduced Neurodegeneration in vivo" @default.
- W4313446715 doi "https://doi.org/10.12974/2309-6179.2022.07.02" @default.
- W4313446715 hasPublicationYear "2022" @default.
- W4313446715 type Work @default.
- W4313446715 citedByCount "0" @default.
- W4313446715 crossrefType "journal-article" @default.
- W4313446715 hasAuthorship W4313446715A5028689490 @default.
- W4313446715 hasAuthorship W4313446715A5074160465 @default.
- W4313446715 hasAuthorship W4313446715A5075246930 @default.
- W4313446715 hasBestOaLocation W43134467151 @default.
- W4313446715 hasConcept C126322002 @default.
- W4313446715 hasConcept C134018914 @default.
- W4313446715 hasConcept C178790620 @default.
- W4313446715 hasConcept C181199279 @default.
- W4313446715 hasConcept C185592680 @default.
- W4313446715 hasConcept C2776151105 @default.
- W4313446715 hasConcept C2776925932 @default.
- W4313446715 hasConcept C2777622882 @default.
- W4313446715 hasConcept C2778389096 @default.
- W4313446715 hasConcept C2778401633 @default.
- W4313446715 hasConcept C2779134260 @default.
- W4313446715 hasConcept C2779491297 @default.
- W4313446715 hasConcept C2780062018 @default.
- W4313446715 hasConcept C2780829032 @default.
- W4313446715 hasConcept C28859421 @default.
- W4313446715 hasConcept C29730261 @default.
- W4313446715 hasConcept C513476851 @default.
- W4313446715 hasConcept C519581460 @default.
- W4313446715 hasConcept C538909803 @default.
- W4313446715 hasConcept C55493867 @default.
- W4313446715 hasConcept C71924100 @default.
- W4313446715 hasConcept C98274493 @default.
- W4313446715 hasConceptScore W4313446715C126322002 @default.
- W4313446715 hasConceptScore W4313446715C134018914 @default.
- W4313446715 hasConceptScore W4313446715C178790620 @default.
- W4313446715 hasConceptScore W4313446715C181199279 @default.
- W4313446715 hasConceptScore W4313446715C185592680 @default.
- W4313446715 hasConceptScore W4313446715C2776151105 @default.
- W4313446715 hasConceptScore W4313446715C2776925932 @default.
- W4313446715 hasConceptScore W4313446715C2777622882 @default.
- W4313446715 hasConceptScore W4313446715C2778389096 @default.
- W4313446715 hasConceptScore W4313446715C2778401633 @default.
- W4313446715 hasConceptScore W4313446715C2779134260 @default.
- W4313446715 hasConceptScore W4313446715C2779491297 @default.
- W4313446715 hasConceptScore W4313446715C2780062018 @default.
- W4313446715 hasConceptScore W4313446715C2780829032 @default.
- W4313446715 hasConceptScore W4313446715C28859421 @default.
- W4313446715 hasConceptScore W4313446715C29730261 @default.
- W4313446715 hasConceptScore W4313446715C513476851 @default.
- W4313446715 hasConceptScore W4313446715C519581460 @default.
- W4313446715 hasConceptScore W4313446715C538909803 @default.
- W4313446715 hasConceptScore W4313446715C55493867 @default.
- W4313446715 hasConceptScore W4313446715C71924100 @default.
- W4313446715 hasConceptScore W4313446715C98274493 @default.
- W4313446715 hasLocation W43134467151 @default.
- W4313446715 hasOpenAccess W4313446715 @default.
- W4313446715 hasPrimaryLocation W43134467151 @default.
- W4313446715 hasRelatedWork W1989354585 @default.
- W4313446715 hasRelatedWork W2015274231 @default.
- W4313446715 hasRelatedWork W2020214793 @default.
- W4313446715 hasRelatedWork W2070656560 @default.
- W4313446715 hasRelatedWork W2112927571 @default.
- W4313446715 hasRelatedWork W2149420888 @default.
- W4313446715 hasRelatedWork W2150354783 @default.
- W4313446715 hasRelatedWork W2325165571 @default.
- W4313446715 hasRelatedWork W3080038642 @default.
- W4313446715 hasRelatedWork W4200289574 @default.
- W4313446715 hasVolume "7" @default.
- W4313446715 isParatext "false" @default.
- W4313446715 isRetracted "false" @default.
- W4313446715 workType "article" @default.