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- W4313447632 abstract "Developing cellular models to study progressive disorders like Alzheimer’s is a challenge due to the unknown initiator of the disease and its slow progression. Recent developments in stem cell technology have made it possible to generate human-specific models such as organoids to study brain development and disease. Organoids are miniature organs that are artificially grown in vitro. Brain organoids are 3D tissues that closely resemble developing human brain. Their important advantage is that they are derived from human pluripotent stem cells. In this pilot study, we are using brain organoids isolated at different days of their growth in combination with quantitative proteomics using isobaric tandem mass tags to define changes in protein contents and amounts within the developing brain, with the goal to apply this tool to study progressive disease pathology." @default.
- W4313447632 created "2023-01-06" @default.
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- W4313447632 date "2023-01-01" @default.
- W4313447632 modified "2023-10-17" @default.
- W4313447632 title "Multiplexed Quantitative Proteomics Analysis of Developing Human Brain Organoids" @default.
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- W4313447632 doi "https://doi.org/10.1007/978-1-0716-2875-1_22" @default.
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