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- W4313447947 abstract "Abstract In patients with low-risk differentiated thyroid cancer (DTC), remnant ablation with radioiodine (RA) after total thyroidectomy (TT) is controversial. No benefits have been demonstrated in terms of mortality or disease-free survival. Recent evidence found that RA did not improve mid-term outcomes. Purpose : to evaluate initial response to treatment and long-term follow-up status in low-risk DTC patients after TT vs. TT+RA. Methods : prospective multicenter non-randomized study; 174 low-risk DTC that underwent TT were recruited and were divided in two groups according to RA (87 ablated and 87 non-ablated). Response to treatment was evaluated between 6-18 months after thyroidectomy and at the end of follow-up with thyroglobulin, anti-thyroglobulin antibodies levels and neck ultrasonography. Results: baseline characteristics of both groups were similar. Ablated patients: median age 45.5 years, 84% females, 95.4% papillary thyroid carcinoma (PTC), mean tumor size 16mm; non-ablated: median age 45 years, 88.5% females, 96.6% PTC, mean tumor size 14 mm. Response to initial treatment was similar between both groups, with less than 2% of structural incomplete response. Final status was evaluated in 139 cases after a median follow-up of 60 months. Among ablated patients, 82.8% had no evidence of disease (NED), 12% had an indeterminate response (IR) and 5% a biochemical incomplete response (BIR). Non-ablated patients had NED in 90%, IR in 8.7% and BIR in 1.2%. No statistical difference was found between groups (p=0.29). No patient had evidence of structural disease at the end of follow-up. Conclusions: our findings support the recommendation against routine RA in low-risk DTC patients." @default.
- W4313447947 created "2023-01-06" @default.
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- W4313447947 date "2022-12-20" @default.
- W4313447947 modified "2023-10-16" @default.
- W4313447947 title "Is radioiodine ablation with 30 mCi 131I necessary in low-risk thyroid cancer patients? Results from a long-term follow-up prospective study." @default.
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- W4313447947 doi "https://doi.org/10.21203/rs.3.rs-2359357/v1" @default.
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