Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313448574> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4313448574 abstract "Abstract Lifecourse Mendelian randomization is a causal inference technique which harnesses genetic variants with time-varying effects to develop insight into the influence of age-dependent lifestyle factors on disease risk. Here, we apply this approach to evaluate whether childhood adiposity has a direct consequence on 8 major disease endpoints by analysing data on first-degree relatives from the UK Biobank study. Our findings suggest that, whilst childhood adiposity increases later risk of outcomes such as heart disease (odds ratio (OR) = 1.15, 95% CI = 1.07 to 1.23, P = 7.8x10 − 5 ) and diabetes (OR = 1.43, 95% CI = 1.31 to 1.56, P = 9.4x10 − 15 ), these findings are likely attributed to a sustained influence of adiposity for many years over the lifecourse. Likewise, we found evidence that sustained adiposity over the lifecourse increases risk of lung cancer, which was partially mediated by lifetime smoking index. In contrast, using family history data provided evidence that being overweight in childhood may have a protective effect on risk of breast cancer (OR = 0.87, 95% CI = 0.78 to 0.97, P = 0.01), corroborating findings from observational studies and large-scale genetic consortia. Large-scale family disease history data can provide a complementary source of evidence for epidemiological studies to exploit, particularly given that they are likely more robust to sources of selection bias (e.g. survival bias) compared to conventional case control studies. Leveraging these data using approaches such as lifecourse Mendelian randomization can help elucidate additional layers of evidence to dissect age-dependent effects on disease risk." @default.
- W4313448574 created "2023-01-06" @default.
- W4313448574 creator A5015814169 @default.
- W4313448574 creator A5026457032 @default.
- W4313448574 creator A5055374455 @default.
- W4313448574 creator A5076124471 @default.
- W4313448574 date "2022-12-20" @default.
- W4313448574 modified "2023-10-12" @default.
- W4313448574 title "Leveraging family history data to disentangle time-varying effects on disease risk using lifecourse Mendelian randomization" @default.
- W4313448574 cites W2106036991 @default.
- W4313448574 cites W2796842426 @default.
- W4313448574 cites W2965936319 @default.
- W4313448574 cites W3011942165 @default.
- W4313448574 cites W3014555327 @default.
- W4313448574 cites W3015900446 @default.
- W4313448574 cites W3195291379 @default.
- W4313448574 cites W4225016415 @default.
- W4313448574 cites W4225987030 @default.
- W4313448574 doi "https://doi.org/10.21203/rs.3.rs-1862835/v1" @default.
- W4313448574 hasPublicationYear "2022" @default.
- W4313448574 type Work @default.
- W4313448574 citedByCount "0" @default.
- W4313448574 crossrefType "posted-content" @default.
- W4313448574 hasAuthorship W4313448574A5015814169 @default.
- W4313448574 hasAuthorship W4313448574A5026457032 @default.
- W4313448574 hasAuthorship W4313448574A5055374455 @default.
- W4313448574 hasAuthorship W4313448574A5076124471 @default.
- W4313448574 hasBestOaLocation W43134485741 @default.
- W4313448574 hasConcept C104317684 @default.
- W4313448574 hasConcept C107130276 @default.
- W4313448574 hasConcept C116567970 @default.
- W4313448574 hasConcept C126322002 @default.
- W4313448574 hasConcept C135763542 @default.
- W4313448574 hasConcept C142724271 @default.
- W4313448574 hasConcept C144024400 @default.
- W4313448574 hasConcept C149923435 @default.
- W4313448574 hasConcept C156957248 @default.
- W4313448574 hasConcept C158600405 @default.
- W4313448574 hasConcept C23131810 @default.
- W4313448574 hasConcept C2779134260 @default.
- W4313448574 hasConcept C2779901538 @default.
- W4313448574 hasConcept C2780221984 @default.
- W4313448574 hasConcept C2780586474 @default.
- W4313448574 hasConcept C2781179581 @default.
- W4313448574 hasConcept C2993967602 @default.
- W4313448574 hasConcept C40423286 @default.
- W4313448574 hasConcept C54355233 @default.
- W4313448574 hasConcept C60644358 @default.
- W4313448574 hasConcept C71924100 @default.
- W4313448574 hasConcept C86803240 @default.
- W4313448574 hasConceptScore W4313448574C104317684 @default.
- W4313448574 hasConceptScore W4313448574C107130276 @default.
- W4313448574 hasConceptScore W4313448574C116567970 @default.
- W4313448574 hasConceptScore W4313448574C126322002 @default.
- W4313448574 hasConceptScore W4313448574C135763542 @default.
- W4313448574 hasConceptScore W4313448574C142724271 @default.
- W4313448574 hasConceptScore W4313448574C144024400 @default.
- W4313448574 hasConceptScore W4313448574C149923435 @default.
- W4313448574 hasConceptScore W4313448574C156957248 @default.
- W4313448574 hasConceptScore W4313448574C158600405 @default.
- W4313448574 hasConceptScore W4313448574C23131810 @default.
- W4313448574 hasConceptScore W4313448574C2779134260 @default.
- W4313448574 hasConceptScore W4313448574C2779901538 @default.
- W4313448574 hasConceptScore W4313448574C2780221984 @default.
- W4313448574 hasConceptScore W4313448574C2780586474 @default.
- W4313448574 hasConceptScore W4313448574C2781179581 @default.
- W4313448574 hasConceptScore W4313448574C2993967602 @default.
- W4313448574 hasConceptScore W4313448574C40423286 @default.
- W4313448574 hasConceptScore W4313448574C54355233 @default.
- W4313448574 hasConceptScore W4313448574C60644358 @default.
- W4313448574 hasConceptScore W4313448574C71924100 @default.
- W4313448574 hasConceptScore W4313448574C86803240 @default.
- W4313448574 hasLocation W43134485741 @default.
- W4313448574 hasOpenAccess W4313448574 @default.
- W4313448574 hasPrimaryLocation W43134485741 @default.
- W4313448574 hasRelatedWork W1972696558 @default.
- W4313448574 hasRelatedWork W2015148400 @default.
- W4313448574 hasRelatedWork W2198763731 @default.
- W4313448574 hasRelatedWork W2401682123 @default.
- W4313448574 hasRelatedWork W2755211944 @default.
- W4313448574 hasRelatedWork W3111078146 @default.
- W4313448574 hasRelatedWork W4281628584 @default.
- W4313448574 hasRelatedWork W4290988639 @default.
- W4313448574 hasRelatedWork W4306658544 @default.
- W4313448574 hasRelatedWork W4313448574 @default.
- W4313448574 isParatext "false" @default.
- W4313448574 isRetracted "false" @default.
- W4313448574 workType "article" @default.