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• W4313448653 abstract "Abstract Background: The antibiotic resistance of pathogenic microbes due to the overuse of antibiotics is a growing threat to the public health and can eventually reduce the therapeutic effects of antibiotics. Hydrogel-based systems for local delivery of antibiotics can be a solution to this problem. Metal-organic frameworks (MOFs) have received considerable interest for use as antimicrobial materials due to their high porosity, large surface area to volume, diverse structures, and tunable topologies. Methods: In this study, we developed MOF-encapsulated and dual (photo & chemical)-crosslinkable alginate hydrogel as an antimicrobial scaffold. We synthesized antimicrobial Cu(AZPY)-MOF using solvothermal reaction and encapsulated them in an alginate-based hydrogel via visible light photo-crosslinking and calcium ion-induced chemical-crosslinking processes. Results: Powder X-ray diffraction, Fourier-transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy confirmed the successful fabrication of Cu(AZPY)-MOF encapsulated alginate hydrogel. The mechanical strength of the dual-crosslinked hydrogels was better than that of the photo-crosslinked hydrogel. Encapsulation of Cu(AZPY)-MOF in an alginate hydrogel resulted in a further increase in the mechanical strength of the hydrogel owing to the additional interaction of alginate with Cu-MOF. Moreover, the Cu(AZPY)-MOF encapsulated alginate hydrogel exhibited excellent antibacterial and antifungal properties against two bacterial strains (i.e., MRSA and S. mutans ) and one fungal strain ( C. albicans ) as well as negligible cytotoxicity toward MEFs. Conclusions: The antimicrobial agents encapsulated dual-crosslinkable alginate hydrogel developed in this study is a promising candidate for use in tissue engineering and biomedical field." @default.
• W4313448653 created "2023-01-06" @default.
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• W4313448653 date "2022-12-20" @default.
• W4313448653 modified "2023-10-12" @default.
• W4313448653 title "Injectable bioactive copper-based metal organic framework embedded dual-crosslinked alginate hydrogel for potential antimicrobial applications" @default.
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• W4313448653 doi "https://doi.org/10.21203/rs.3.rs-2352401/v1" @default.
• W4313448653 hasPublicationYear "2022" @default.
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