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• W4313450538 endingPage "114430" @default.
• W4313450538 startingPage "114430" @default.
• W4313450538 abstract "The effect of dietary lead on the intestinal microbiome has not been fully elucidated. To determine if there was an association between microflora modulation, predicted functional genes, and Pb exposure, mice were provided diets amended with increasing concentrations of a single lead compound, lead acetate, or a well characterized complex reference soil containing lead, i.e. 6.25–25 mg/kg Pb acetate (PbOAc) or 7.5–30 mg/kg Pb in reference soil SRM 2710a having 0.552 % Pb among other heavy metals such as Cd. Feces and ceca were collected following 9 days of treatment and the microbiome analyzed by 16 S rRNA gene sequencing. Treatment effects on the microbiome were observed in both feces and ceca of mice. Changes in the cecal microbiomes of mice fed Pb as Pb acetate or as a constituent in SRM 2710a were statistically different except for a few exceptions regardless of dietary source. This was accompanied by increased average abundance of functional genes associated with metal resistance, including those related to siderophore synthesis and arsenic and/or mercury detoxification. Akkermansia, a common gut bacterium, was the highest ranked species in control microbiomes whereas Lactobacillus ranked highest in treated mice. Firmicutes/Bacteroidetes ratios in the ceca of SRM 2710a treated mice increased more than with PbOAc, suggestive of changes in gut microbiome metabolism that promotes obesity. Predicted functional gene average abundance related to carbohydrate, lipid, and/or fatty acid biosynthesis and degradation were greater in the cecal microbiome of SRM 2710a treated mice. Bacilli/Clostridia increased in the ceca of PbOAc treated mice and may be indicative of increased risk of host sepsis. Family Deferribacteraceae also was modulated by PbOAc or SRM 2710a possibly impacting inflammatory response. Understanding the relationship between microbiome composition, predicted functional genes, and Pb concentration, especially in soil, may provide new insights into the utility of various remediation methodologies that minimize dysbiosis and modulate health effects, thus assisting in the selection of an optimal treatment for contaminated sites." @default.
• W4313450538 created "2023-01-06" @default.
• W4313450538 creator A5002467711 @default.
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• W4313450538 date "2023-01-01" @default.
• W4313450538 modified "2023-09-30" @default.
• W4313450538 title "Dietary lead modulates the mouse intestinal microbiome: Subacute exposure to lead acetate and lead contaminated soil" @default.
• W4313450538 cites W1176298813 @default.
• W4313450538 cites W1486016704 @default.
• W4313450538 cites W1939958871 @default.
• W4313450538 cites W1940472683 @default.
• W4313450538 cites W1964227994 @default.
• W4313450538 cites W1970118885 @default.
• W4313450538 cites W1970283519 @default.
• W4313450538 cites W1971147610 @default.
• W4313450538 cites W1971252694 @default.
• W4313450538 cites W1971415551 @default.
• W4313450538 cites W1974697222 @default.
• W4313450538 cites W1978654378 @default.
• W4313450538 cites W1981750793 @default.
• W4313450538 cites W1988066281 @default.
• W4313450538 cites W1989121514 @default.
• W4313450538 cites W1992387624 @default.
• W4313450538 cites W1995824183 @default.
• W4313450538 cites W2002672183 @default.
• W4313450538 cites W2003909757 @default.
• W4313450538 cites W2007941982 @default.
• W4313450538 cites W2008370788 @default.
• W4313450538 cites W2009457173 @default.
• W4313450538 cites W2021965815 @default.
• W4313450538 cites W2022414378 @default.
• W4313450538 cites W2033915783 @default.
• W4313450538 cites W2034285706 @default.
• W4313450538 cites W2038217946 @default.
• W4313450538 cites W2043221915 @default.
• W4313450538 cites W2046605903 @default.
• W4313450538 cites W2055491066 @default.
• W4313450538 cites W2071221561 @default.
• W4313450538 cites W2072329197 @default.
• W4313450538 cites W2077045509 @default.
• W4313450538 cites W2079347307 @default.
• W4313450538 cites W2082092506 @default.
• W4313450538 cites W2091437065 @default.
• W4313450538 cites W2095219176 @default.
• W4313450538 cites W2106795996 @default.
• W4313450538 cites W2108718991 @default.
• W4313450538 cites W2111973517 @default.
• W4313450538 cites W2120686070 @default.
• W4313450538 cites W2121346848 @default.
• W4313450538 cites W2124057752 @default.
• W4313450538 cites W2125252497 @default.
• W4313450538 cites W2134142371 @default.
• W4313450538 cites W2142536690 @default.
• W4313450538 cites W2145538105 @default.
• W4313450538 cites W2145662137 @default.
• W4313450538 cites W2152562424 @default.
• W4313450538 cites W2253137654 @default.
• W4313450538 cites W2331541864 @default.
• W4313450538 cites W2406534203 @default.
• W4313450538 cites W2512052924 @default.
• W4313450538 cites W2530246184 @default.
• W4313450538 cites W2537830410 @default.
• W4313450538 cites W2563315795 @default.
• W4313450538 cites W2566136758 @default.
• W4313450538 cites W2581326447 @default.
• W4313450538 cites W2589693495 @default.
• W4313450538 cites W2613536301 @default.
• W4313450538 cites W2745124265 @default.
• W4313450538 cites W2757917056 @default.
• W4313450538 cites W2759660820 @default.
• W4313450538 cites W2766358903 @default.
• W4313450538 cites W2766840884 @default.
• W4313450538 cites W2775829685 @default.
• W4313450538 cites W2791611068 @default.
• W4313450538 cites W2791645513 @default.
• W4313450538 cites W2792654284 @default.
• W4313450538 cites W2810336477 @default.
• W4313450538 cites W2891465306 @default.
• W4313450538 cites W2898434769 @default.
• W4313450538 cites W2913297401 @default.
• W4313450538 cites W2918256091 @default.
• W4313450538 cites W2977217151 @default.
• W4313450538 cites W2977870980 @default.
• W4313450538 cites W2997947343 @default.
• W4313450538 cites W3012411903 @default.
• W4313450538 cites W3030441098 @default.
• W4313450538 cites W3082231844 @default.
• W4313450538 cites W3114405331 @default.
• W4313450538 cites W3133090516 @default.
• W4313450538 cites W3134616459 @default.
• W4313450538 cites W3140902937 @default.
• W4313450538 cites W3160273821 @default.
• W4313450538 cites W3184180527 @default.

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