Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313451231> ?p ?o ?g. }
- W4313451231 abstract "The evolution of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has followed similar trends as other RNA viruses, such as human immunodeficiency virus type 1 and the influenza A virus. Rapid initial diversification was followed by strong competition and a rapid succession of dominant variants. Host-initiated RNA editing has been the primary mechanism for introducing mutations. A significant number of mutations detrimental to viral replication have been quickly purged. Fixed mutations are mostly diversifying mutations selected for host adaptation and immune evasion, with the latter accounting for the majority of the mutations. However, immune evasion often comes at the cost of functionality, and thus, optimal functionality is still far from being accomplished. Instead, selection for antibody-escaping variants and accumulation of near-neutral mutations have led to suboptimal codon usage and reduced replicative capacity, as demonstrated in non-respiratory cell lines. Beneficial adaptation of the virus includes reduced infectivity in lung tissues and increased tropism for the upper airway, resulting in shorter incubation periods, milder diseases, and more efficient transmission between people." @default.
- W4313451231 created "2023-01-06" @default.
- W4313451231 creator A5014782404 @default.
- W4313451231 date "2023-01-03" @default.
- W4313451231 modified "2023-10-05" @default.
- W4313451231 title "Attenuation and Degeneration of SARS-CoV-2 Despite Adaptive Evolution" @default.
- W4313451231 cites W1998725525 @default.
- W4313451231 cites W2001468498 @default.
- W4313451231 cites W2001949677 @default.
- W4313451231 cites W2070872421 @default.
- W4313451231 cites W2082589219 @default.
- W4313451231 cites W2100898084 @default.
- W4313451231 cites W2104474203 @default.
- W4313451231 cites W2110471430 @default.
- W4313451231 cites W2111904018 @default.
- W4313451231 cites W2115181164 @default.
- W4313451231 cites W2123386205 @default.
- W4313451231 cites W2137051059 @default.
- W4313451231 cites W2156891661 @default.
- W4313451231 cites W2416193592 @default.
- W4313451231 cites W2578670470 @default.
- W4313451231 cites W2739789502 @default.
- W4313451231 cites W2807395067 @default.
- W4313451231 cites W2903736884 @default.
- W4313451231 cites W2984592488 @default.
- W4313451231 cites W2996877521 @default.
- W4313451231 cites W3004912618 @default.
- W4313451231 cites W3011483298 @default.
- W4313451231 cites W3025586072 @default.
- W4313451231 cites W3025620739 @default.
- W4313451231 cites W3032989470 @default.
- W4313451231 cites W3034529698 @default.
- W4313451231 cites W3035786310 @default.
- W4313451231 cites W3043431476 @default.
- W4313451231 cites W3044321933 @default.
- W4313451231 cites W3048714202 @default.
- W4313451231 cites W3092140113 @default.
- W4313451231 cites W3093768302 @default.
- W4313451231 cites W3094367033 @default.
- W4313451231 cites W3113376253 @default.
- W4313451231 cites W3130825974 @default.
- W4313451231 cites W3162281488 @default.
- W4313451231 cites W3175068151 @default.
- W4313451231 cites W3179423943 @default.
- W4313451231 cites W3193641425 @default.
- W4313451231 cites W3193682077 @default.
- W4313451231 cites W3193925370 @default.
- W4313451231 cites W3194208617 @default.
- W4313451231 cites W3200452118 @default.
- W4313451231 cites W3206346080 @default.
- W4313451231 cites W3212694953 @default.
- W4313451231 cites W3216169886 @default.
- W4313451231 cites W4200536824 @default.
- W4313451231 cites W4200625712 @default.
- W4313451231 cites W4205380803 @default.
- W4313451231 cites W4206153788 @default.
- W4313451231 cites W4207050895 @default.
- W4313451231 cites W4210252764 @default.
- W4313451231 cites W4210308999 @default.
- W4313451231 cites W4210369316 @default.
- W4313451231 cites W4210463078 @default.
- W4313451231 cites W4210866882 @default.
- W4313451231 cites W4210941802 @default.
- W4313451231 cites W4211065626 @default.
- W4313451231 cites W4214767539 @default.
- W4313451231 cites W4220730196 @default.
- W4313451231 cites W4220834863 @default.
- W4313451231 cites W4220844906 @default.
- W4313451231 cites W4220901163 @default.
- W4313451231 cites W4221085637 @default.
- W4313451231 cites W4224862904 @default.
- W4313451231 cites W4225691034 @default.
- W4313451231 cites W4246230396 @default.
- W4313451231 cites W4280573833 @default.
- W4313451231 cites W4281383093 @default.
- W4313451231 cites W4281552311 @default.
- W4313451231 cites W4282833244 @default.
- W4313451231 cites W4283641916 @default.
- W4313451231 cites W4284899260 @default.
- W4313451231 cites W4286587254 @default.
- W4313451231 cites W4289517359 @default.
- W4313451231 cites W4289521716 @default.
- W4313451231 cites W4292553048 @default.
- W4313451231 cites W4292622968 @default.
- W4313451231 cites W4292673873 @default.
- W4313451231 cites W4293212486 @default.
- W4313451231 cites W4295346375 @default.
- W4313451231 cites W4295853735 @default.
- W4313451231 cites W4296280380 @default.
- W4313451231 cites W4297261268 @default.
- W4313451231 cites W4297537362 @default.
- W4313451231 cites W4308077151 @default.
- W4313451231 cites W4308792217 @default.
- W4313451231 doi "https://doi.org/10.7759/cureus.33316" @default.
- W4313451231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36741655" @default.
- W4313451231 hasPublicationYear "2023" @default.
- W4313451231 type Work @default.
- W4313451231 citedByCount "1" @default.
- W4313451231 countsByYear W43134512312023 @default.
- W4313451231 crossrefType "journal-article" @default.