FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313451655> ?p ?o ?g. }

• W4313451655 abstract "Abstract Orsellinic acid (OA) derivatives are produced by filamentous fungi using nonreducing polyketide synthases (nrPKSs). The chain‐releasing thioesterase (TE) domains of such nrPKSs were proposed to also catalyze dimerization to yield didepsides, such as lecanoric acid. Here, we use combinatorial domain exchanges, domain dissections and reconstitutions to reveal that the TE domain of the lecanoric acid synthase Preu6 of Preussia isomera must collaborate with the starter acyl transferase (SAT) domain from the same nrPKS. We show that artificial SAT‐TE fusion proteins are highly effective catalysts and reprogram the ketide homologation chassis to form didepsides. We also demonstrate that dissected SAT and TE domains of Preu6 physically interact, and SAT and TE domains of OA‐synthesizing nrPKSs may co‐evolve. Our work highlights an unexpected domain–domain interaction in nrPKSs that must be considered for the combinatorial biosynthesis of unnatural didepsides, depsidones, and diphenyl ethers." @default.
• W4313451655 created "2023-01-06" @default.
• W4313451655 creator A5014533748 @default.
• W4313451655 creator A5021843263 @default.
• W4313451655 creator A5028404773 @default.
• W4313451655 creator A5029517091 @default.
• W4313451655 creator A5031160298 @default.
• W4313451655 creator A5033775618 @default.
• W4313451655 creator A5045802702 @default.
• W4313451655 creator A5054578682 @default.
• W4313451655 creator A5059592548 @default.
• W4313451655 creator A5074004958 @default.
• W4313451655 creator A5077497644 @default.
• W4313451655 creator A5086559201 @default.
• W4313451655 creator A5089412381 @default.
• W4313451655 date "2022-12-29" @default.
• W4313451655 modified "2023-10-16" @default.
• W4313451655 title "Didepside Formation by the Nonreducing Polyketide Synthase Preu6 of <i>Preussia isomera</i> Requires Interaction of Starter Acyl Transferase and Thioesterase Domains" @default.
• W4313451655 cites W1965778223 @default.
• W4313451655 cites W1986893248 @default.
• W4313451655 cites W1989773731 @default.
• W4313451655 cites W1994444060 @default.
• W4313451655 cites W2049505804 @default.
• W4313451655 cites W2060285940 @default.
• W4313451655 cites W2063224770 @default.
• W4313451655 cites W2086218465 @default.
• W4313451655 cites W2160122984 @default.
• W4313451655 cites W2322408166 @default.
• W4313451655 cites W2603886489 @default.
• W4313451655 cites W2901728908 @default.
• W4313451655 cites W2904804905 @default.
• W4313451655 cites W2939447905 @default.
• W4313451655 cites W3012495848 @default.
• W4313451655 cites W3081019927 @default.
• W4313451655 cites W3097771693 @default.
• W4313451655 cites W3203074014 @default.
• W4313451655 cites W4229003507 @default.
• W4313451655 cites W4281686373 @default.
• W4313451655 cites W4285393175 @default.
• W4313451655 doi "https://doi.org/10.1002/ange.202214379" @default.
• W4313451655 hasPublicationYear "2022" @default.
• W4313451655 type Work @default.
• W4313451655 citedByCount "0" @default.
• W4313451655 crossrefType "journal-article" @default.
• W4313451655 hasAuthorship W4313451655A5014533748 @default.
• W4313451655 hasAuthorship W4313451655A5021843263 @default.
• W4313451655 hasAuthorship W4313451655A5028404773 @default.
• W4313451655 hasAuthorship W4313451655A5029517091 @default.
• W4313451655 hasAuthorship W4313451655A5031160298 @default.
• W4313451655 hasAuthorship W4313451655A5033775618 @default.
• W4313451655 hasAuthorship W4313451655A5045802702 @default.
• W4313451655 hasAuthorship W4313451655A5054578682 @default.
• W4313451655 hasAuthorship W4313451655A5059592548 @default.
• W4313451655 hasAuthorship W4313451655A5074004958 @default.
• W4313451655 hasAuthorship W4313451655A5077497644 @default.
• W4313451655 hasAuthorship W4313451655A5086559201 @default.
• W4313451655 hasAuthorship W4313451655A5089412381 @default.
• W4313451655 hasConcept C112243037 @default.
• W4313451655 hasConcept C134306372 @default.
• W4313451655 hasConcept C181199279 @default.
• W4313451655 hasConcept C185592680 @default.
• W4313451655 hasConcept C2776376580 @default.
• W4313451655 hasConcept C2777763344 @default.
• W4313451655 hasConcept C2778635478 @default.
• W4313451655 hasConcept C2780622759 @default.
• W4313451655 hasConcept C2780786045 @default.
• W4313451655 hasConcept C2910079589 @default.
• W4313451655 hasConcept C33923547 @default.
• W4313451655 hasConcept C36503486 @default.
• W4313451655 hasConcept C553450214 @default.
• W4313451655 hasConcept C55493867 @default.
• W4313451655 hasConcept C71240020 @default.
• W4313451655 hasConceptScore W4313451655C112243037 @default.
• W4313451655 hasConceptScore W4313451655C134306372 @default.
• W4313451655 hasConceptScore W4313451655C181199279 @default.
• W4313451655 hasConceptScore W4313451655C185592680 @default.
• W4313451655 hasConceptScore W4313451655C2776376580 @default.
• W4313451655 hasConceptScore W4313451655C2777763344 @default.
• W4313451655 hasConceptScore W4313451655C2778635478 @default.
• W4313451655 hasConceptScore W4313451655C2780622759 @default.
• W4313451655 hasConceptScore W4313451655C2780786045 @default.
• W4313451655 hasConceptScore W4313451655C2910079589 @default.
• W4313451655 hasConceptScore W4313451655C33923547 @default.
• W4313451655 hasConceptScore W4313451655C36503486 @default.
• W4313451655 hasConceptScore W4313451655C553450214 @default.
• W4313451655 hasConceptScore W4313451655C55493867 @default.
• W4313451655 hasConceptScore W4313451655C71240020 @default.
• W4313451655 hasFunder F4320321001 @default.
• W4313451655 hasFunder F4320324208 @default.
• W4313451655 hasFunder F4320332299 @default.
• W4313451655 hasIssue "6" @default.
• W4313451655 hasLocation W43134516551 @default.
• W4313451655 hasOpenAccess W4313451655 @default.
• W4313451655 hasPrimaryLocation W43134516551 @default.
• W4313451655 hasRelatedWork W1973421302 @default.
• W4313451655 hasRelatedWork W1994361647 @default.
• W4313451655 hasRelatedWork W1997115583 @default.
• W4313451655 hasRelatedWork W2010050893 @default.
• W4313451655 hasRelatedWork W2049804099 @default.
• W4313451655 hasRelatedWork W2082855407 @default.

• next