Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313452129> ?p ?o ?g. }
- W4313452129 endingPage "105782" @default.
- W4313452129 startingPage "105782" @default.
- W4313452129 abstract "Cocaine acts by inhibiting plasma membrane dopamine transporter (DAT) function and altering its surface expression. The precise manner and mechanism by which cocaine regulates DAT trafficking, especially at neuronal processes, are poorly understood. In this study, we engineered and validated the use of DAT-pHluorin for studying DAT localization and its dynamic trafficking at neuronal processes of cultured mouse midbrain neurons. We demonstrate that unlike neuronal soma and dendrites, which contain a majority of the DATs in weakly acidic intracellular compartments, axonal DATs at both shafts and boutons are primarily (75%) localized to the plasma membrane, whereas large varicosities contain abundant intracellular DAT within acidic intracellular structures. We also demonstrate that cocaine exposure leads to a Synaptojanin1-sensitive DAT internalization process followed by membrane reinsertion that lasts for days. Thus, our study reveals the previously unknown dynamics and molecular regulation for cocaine-regulated DAT trafficking in neuronal processes." @default.
- W4313452129 created "2023-01-06" @default.
- W4313452129 creator A5007521332 @default.
- W4313452129 creator A5050291705 @default.
- W4313452129 creator A5053585063 @default.
- W4313452129 creator A5064655521 @default.
- W4313452129 creator A5075032928 @default.
- W4313452129 creator A5077746312 @default.
- W4313452129 creator A5080755916 @default.
- W4313452129 creator A5083896815 @default.
- W4313452129 date "2023-01-01" @default.
- W4313452129 modified "2023-09-29" @default.
- W4313452129 title "Cocaine-regulated trafficking of dopamine transporters in cultured neurons revealed by a pH sensitive reporter" @default.
- W4313452129 cites W1507545195 @default.
- W4313452129 cites W1546941611 @default.
- W4313452129 cites W1602580383 @default.
- W4313452129 cites W1607128430 @default.
- W4313452129 cites W1645031292 @default.
- W4313452129 cites W1657446979 @default.
- W4313452129 cites W1851407835 @default.
- W4313452129 cites W1924669955 @default.
- W4313452129 cites W1965940344 @default.
- W4313452129 cites W1971751319 @default.
- W4313452129 cites W1971840849 @default.
- W4313452129 cites W1978842225 @default.
- W4313452129 cites W1987683081 @default.
- W4313452129 cites W1988456793 @default.
- W4313452129 cites W1988472272 @default.
- W4313452129 cites W1988760898 @default.
- W4313452129 cites W1989459745 @default.
- W4313452129 cites W1999290808 @default.
- W4313452129 cites W2001532503 @default.
- W4313452129 cites W2008643711 @default.
- W4313452129 cites W2013503066 @default.
- W4313452129 cites W2014753160 @default.
- W4313452129 cites W2016166286 @default.
- W4313452129 cites W2019647316 @default.
- W4313452129 cites W2020405606 @default.
- W4313452129 cites W2022292972 @default.
- W4313452129 cites W2030642011 @default.
- W4313452129 cites W2031907844 @default.
- W4313452129 cites W2048656990 @default.
- W4313452129 cites W2057024460 @default.
- W4313452129 cites W2057316908 @default.
- W4313452129 cites W2058568944 @default.
- W4313452129 cites W2061679276 @default.
- W4313452129 cites W2067087475 @default.
- W4313452129 cites W2069049686 @default.
- W4313452129 cites W2071196621 @default.
- W4313452129 cites W2072440625 @default.
- W4313452129 cites W2075832622 @default.
- W4313452129 cites W2076361891 @default.
- W4313452129 cites W2077254660 @default.
- W4313452129 cites W2082426787 @default.
- W4313452129 cites W2082455760 @default.
- W4313452129 cites W2083532524 @default.
- W4313452129 cites W2083767904 @default.
- W4313452129 cites W2085113917 @default.
- W4313452129 cites W2089157578 @default.
- W4313452129 cites W2089885121 @default.
- W4313452129 cites W2092101573 @default.
- W4313452129 cites W2093414544 @default.
- W4313452129 cites W2095233739 @default.
- W4313452129 cites W2095266989 @default.
- W4313452129 cites W2099540110 @default.
- W4313452129 cites W2101310032 @default.
- W4313452129 cites W2106477171 @default.
- W4313452129 cites W2110328640 @default.
- W4313452129 cites W2144420636 @default.
- W4313452129 cites W2145533695 @default.
- W4313452129 cites W2148137149 @default.
- W4313452129 cites W2161005221 @default.
- W4313452129 cites W2166348969 @default.
- W4313452129 cites W2265945699 @default.
- W4313452129 cites W2302615100 @default.
- W4313452129 cites W2315192691 @default.
- W4313452129 cites W2499228440 @default.
- W4313452129 cites W2576833703 @default.
- W4313452129 cites W2590442776 @default.
- W4313452129 cites W2601351914 @default.
- W4313452129 cites W2613875177 @default.
- W4313452129 cites W2625698191 @default.
- W4313452129 cites W269800955 @default.
- W4313452129 cites W2766537970 @default.
- W4313452129 cites W2770119180 @default.
- W4313452129 cites W2797336150 @default.
- W4313452129 cites W2809799315 @default.
- W4313452129 cites W2888087982 @default.
- W4313452129 cites W2951064616 @default.
- W4313452129 cites W2967836394 @default.
- W4313452129 cites W2996756368 @default.
- W4313452129 cites W3021215519 @default.
- W4313452129 cites W3083642784 @default.
- W4313452129 cites W3086856825 @default.
- W4313452129 cites W3107518730 @default.
- W4313452129 cites W3127127771 @default.
- W4313452129 cites W3132109692 @default.
- W4313452129 cites W3207511828 @default.