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- W4313452309 endingPage "109593" @default.
- W4313452309 startingPage "109593" @default.
- W4313452309 abstract "Chimeric antigen receptor (CAR) T cell therapy is introduced as an effective, rapidly evolving therapeutic to treat cancer, especially cancers derived from hematological cells, such as B cells. CAR T cell gene constructs combine a tumor-targeting device coupled to the T cell receptor (TCR) zeta chain domain with different signaling domains such as domains derived from CD28 or 4-1BB (CD137). The incorporation of each specific co-stimulatory domain targets the immunometabolic pathways of CAR T cells as well as other signaling pathways. Defining the immunometabolic and signaling pathways by which CAR T cells become and remain active, survive, and eliminate their targets may represent a huge step forward in this relatively young research field as the CAR gene can be tailored to gain optimal function also for solid tumors with elaborate immunosuppression and protective stroma. There is a close relationship between different signaling domains applied in CAR T cells, and difficult to evaluate the benefit from different tested CAR gene constructs. In this review, we attempt to collect the latest findings regarding the CAR T cell signaling pathways that affect immunometabolic pathways." @default.
- W4313452309 created "2023-01-06" @default.
- W4313452309 creator A5018516346 @default.
- W4313452309 creator A5028354492 @default.
- W4313452309 creator A5041806701 @default.
- W4313452309 creator A5063027590 @default.
- W4313452309 date "2023-01-01" @default.
- W4313452309 modified "2023-09-24" @default.
- W4313452309 title "The signaling and the metabolic differences of various CAR T cell designs" @default.
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