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- W4313453357 abstract "B lymphocytes recognize bacterial or viral antigens via different classes of the B cell antigen receptor (BCR). Protrusive structures termed microvilli cover lymphocyte surfaces, and are thought to perform sensory functions in screening antigen-bearing surfaces. Here, we have used lattice light-sheet microscopy in combination with tailored custom-built 4D image analysis to study the cell-surface topography of B cells of the Ramos Burkitt's Lymphoma line and the spatiotemporal organization of the IgM-BCR. Ramos B-cell surfaces were found to form dynamic networks of elevated ridges bridging individual microvilli. A fraction of membrane-localized IgM-BCR was found in clusters, which were mainly associated with the ridges and the microvilli. The dynamic ridge-network organization and the IgM-BCR cluster mobility were linked, and both were controlled by Arp2/3 complex activity. Our results suggest that dynamic topographical features of the cell surface govern the localization and transport of IgM-BCR clusters to facilitate antigen screening by B cells." @default.
- W4313453357 created "2023-01-06" @default.
- W4313453357 creator A5002023600 @default.
- W4313453357 creator A5010283472 @default.
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- W4313453357 creator A5023724538 @default.
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- W4313453357 creator A5090005733 @default.
- W4313453357 date "2023-01-03" @default.
- W4313453357 modified "2023-10-17" @default.
- W4313453357 title "Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters" @default.
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- W4313453357 doi "https://doi.org/10.15252/embj.2022112030" @default.
- W4313453357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36594262" @default.
- W4313453357 hasPublicationYear "2023" @default.
- W4313453357 type Work @default.
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