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- W4313453465 abstract "To determine if very low dose (VLD, 0.5% phenylephrine, 0.1% cyclopentolate) mydriatic microdrop (approximately 7 μL) administration (up to three doses) is non-inferior to low dose (LD, 1% phenylephrine, 0.2% cyclopentolate) mydriatic microdrop administration for ophthalmologist-determined successful retinopathy of prematurity eye examination (ROPEE).Multicentre, prospective, randomised controlled, non-inferiority clinical trial.Four neonatal intensive care units in Aotearoa, New Zealand from October 2019 to September 2021.Infants with a birth weight less than 1250 g or gestational age less than 30+6 weeks and who required a ROPEE.The intervention: microdrop (approximately 7 μL) of VLD (0.5% phenylephrine and 0.1% cyclopentolate) to both eyes, or the comparison: microdrop of LD (1% phenylephrine and 0.2% cyclopentolate) to both eyes. Up to three doses could be administered.The primary outcome measure was an ophthalmologist-determined successful ROPEE.One hundred and fifty preterm infants (LD mean GA=27.4±1.8 weeks, mean birth weight=1011±290 g, VLD mean GA=27.5±1.9 weeks, mean birth weight=1049±281 g,) were randomised. Non-inferiority for successful ROPEE was demonstrated for the VLD group compared with the LD group (VLD successful ROPEE=100%, LD successful ROPEE=100%, 95% CI no continuity correction -0.05 to 0.05) and for Māori (95% CI no continuity correction -0.02 to 0.19).VLD microdrops enable safe and effective screening for ROPEE in both Māori and non-Māori preterm infants.ACTRN12619000795190." @default.
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- W4313453465 date "2023-01-02" @default.
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- W4313453465 title "Low dose or very low dose phenylephrine and cyclopentolate microdrops for retinopathy of prematurity eye examinations (The Little Eye Drop Study): a randomised controlled non-inferiority trial" @default.
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- W4313453465 doi "https://doi.org/10.1136/archdischild-2022-324929" @default.
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