FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313453577> ?p ?o ?g. }

• W4313453577 endingPage "1680" @default.
• W4313453577 startingPage "1663" @default.
• W4313453577 abstract "Immune checkpoint inhibitors (ICIs) have displayed potential efficacy in triple-negative breast cancer (TNBC) treatment, while only a minority of patients benefit from ICI therapy currently. Although activation of the innate immune stimulator of interferon genes (STING) pathway potentiates antitumor immunity and thus sensitizes tumors to ICIs, the efficient tumor penetration of STING agonists remains critically challenging. Herein, we prepare a tumor-penetrating neotype neutrophil cytopharmaceutical (NEs@STING-Mal-NP) with liposomal STING agonists conjugating on the surface of neutrophils, which is different from the typical neutrophil cytopharmaceutical that loads drugs inside the neutrophils. We show NEs@STING-Mal-NP that inherit the merits of neutrophils including proactive tumor vascular extravasation and tissue penetration significantly boost the tumor penetration of STING agonists. Moreover, the backpacked liposomal STING agonists can be released in response to hyaluronidase rich in the tumor environment, leading to enhanced uptake by tumor-infiltrating immune cells and tumor cells. Thus, NEs@STING-Mal-NP effectively activate the STING pathway and reinvigorate the tumor environment through converting macrophages and neutrophils to antitumor phenotypes, promoting the maturation of dendritic cells, and enhancing the infiltration and tumoricidal ability of T cells. Specifically, this cytopharmaceutical displays a significant inhibition on tumor growth and prolongs the survival of TNBC-bearing mice when combined with ICIs. We demonstrate that neutrophils serve as promising vehicles for delivering STING agonists throughout solid tumors and the developed neutrophil cytopharmaceuticals with backpacked STING agonists exhibit huge potential in boosting the immunotherapy of ICIs." @default.
• W4313453577 created "2023-01-06" @default.
• W4313453577 creator A5004853165 @default.
• W4313453577 creator A5014105007 @default.
• W4313453577 creator A5037371066 @default.
• W4313453577 creator A5040546337 @default.
• W4313453577 creator A5046996087 @default.
• W4313453577 creator A5055493931 @default.
• W4313453577 creator A5058303518 @default.
• W4313453577 creator A5061579277 @default.
• W4313453577 creator A5073520199 @default.
• W4313453577 creator A5086750051 @default.
• W4313453577 creator A5087161247 @default.
• W4313453577 date "2023-01-03" @default.
• W4313453577 modified "2023-10-18" @default.
• W4313453577 title "Sensitizing Tumors to Immune Checkpoint Blockage via STING Agonists Delivered by Tumor-Penetrating Neutrophil Cytopharmaceuticals" @default.
• W4313453577 cites W1994826332 @default.
• W4313453577 cites W2023962283 @default.
• W4313453577 cites W2027925515 @default.
• W4313453577 cites W2032227357 @default.
• W4313453577 cites W2041302454 @default.
• W4313453577 cites W2056012261 @default.
• W4313453577 cites W2058922167 @default.
• W4313453577 cites W2080631077 @default.
• W4313453577 cites W2097556922 @default.
• W4313453577 cites W2115583652 @default.
• W4313453577 cites W2132413371 @default.
• W4313453577 cites W2135601011 @default.
• W4313453577 cites W2170295495 @default.
• W4313453577 cites W2411767313 @default.
• W4313453577 cites W2466965232 @default.
• W4313453577 cites W2474950788 @default.
• W4313453577 cites W2567813843 @default.
• W4313453577 cites W2580868078 @default.
• W4313453577 cites W2606608340 @default.
• W4313453577 cites W2626252985 @default.
• W4313453577 cites W2776123645 @default.
• W4313453577 cites W2809205318 @default.
• W4313453577 cites W2901307735 @default.
• W4313453577 cites W2904548584 @default.
• W4313453577 cites W2905474711 @default.
• W4313453577 cites W2909554490 @default.
• W4313453577 cites W2911718257 @default.
• W4313453577 cites W2914282788 @default.
• W4313453577 cites W2948773008 @default.
• W4313453577 cites W2949079945 @default.
• W4313453577 cites W2983982331 @default.
• W4313453577 cites W3038007966 @default.
• W4313453577 cites W3044428842 @default.
• W4313453577 cites W3049451994 @default.
• W4313453577 cites W3093916434 @default.
• W4313453577 cites W3101891310 @default.
• W4313453577 cites W3103204231 @default.
• W4313453577 cites W3166682569 @default.
• W4313453577 cites W3191515437 @default.
• W4313453577 cites W3205709074 @default.
• W4313453577 cites W3213834237 @default.
• W4313453577 cites W3216382440 @default.
• W4313453577 cites W4205252391 @default.
• W4313453577 cites W4210499223 @default.
• W4313453577 cites W4248055233 @default.
• W4313453577 cites W4281384840 @default.
• W4313453577 doi "https://doi.org/10.1021/acsnano.2c11764" @default.
• W4313453577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36595464" @default.
• W4313453577 hasPublicationYear "2023" @default.
• W4313453577 type Work @default.
• W4313453577 citedByCount "7" @default.
• W4313453577 countsByYear W43134535772023 @default.
• W4313453577 crossrefType "journal-article" @default.
• W4313453577 hasAuthorship W4313453577A5004853165 @default.
• W4313453577 hasAuthorship W4313453577A5014105007 @default.
• W4313453577 hasAuthorship W4313453577A5037371066 @default.
• W4313453577 hasAuthorship W4313453577A5040546337 @default.
• W4313453577 hasAuthorship W4313453577A5046996087 @default.
• W4313453577 hasAuthorship W4313453577A5055493931 @default.
• W4313453577 hasAuthorship W4313453577A5058303518 @default.
• W4313453577 hasAuthorship W4313453577A5061579277 @default.
• W4313453577 hasAuthorship W4313453577A5073520199 @default.
• W4313453577 hasAuthorship W4313453577A5086750051 @default.
• W4313453577 hasAuthorship W4313453577A5087161247 @default.
• W4313453577 hasConcept C127413603 @default.
• W4313453577 hasConcept C136449434 @default.
• W4313453577 hasConcept C146978453 @default.
• W4313453577 hasConcept C203014093 @default.
• W4313453577 hasConcept C2777349159 @default.
• W4313453577 hasConcept C2777701055 @default.
• W4313453577 hasConcept C2779300339 @default.
• W4313453577 hasConcept C2780674031 @default.
• W4313453577 hasConcept C502942594 @default.
• W4313453577 hasConcept C71924100 @default.
• W4313453577 hasConcept C8891405 @default.
• W4313453577 hasConceptScore W4313453577C127413603 @default.
• W4313453577 hasConceptScore W4313453577C136449434 @default.
• W4313453577 hasConceptScore W4313453577C146978453 @default.
• W4313453577 hasConceptScore W4313453577C203014093 @default.
• W4313453577 hasConceptScore W4313453577C2777349159 @default.
• W4313453577 hasConceptScore W4313453577C2777701055 @default.
• W4313453577 hasConceptScore W4313453577C2779300339 @default.

• next