FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313453642> ?p ?o ?g. }

• W4313453642 endingPage "105760" @default.
• W4313453642 startingPage "105760" @default.
• W4313453642 abstract "Spatial transcriptomics is a novel technique that provides RNA-expression data with tissue-contextual annotations. Quality assessments of such techniques using end-user generated data are often lacking. Here, we evaluated data from the NanoString GeoMx Digital Spatial Profiling (DSP) platform and standard processing pipelines. We queried 72 ROIs from 12 glioma samples, performed replicate experiments of eight samples for validation, and evaluated five external datasets. The data consistently showed vastly different signal intensities between samples and experimental conditions that resulted in biased analysis. We evaluated the performance of alternative normalization strategies and show that quantile normalization can adequately address the technical issues related to the differences in data distributions. Compared to bulk RNA sequencing, NanoString DSP data show a limited dynamic range which underestimates differences between conditions. Weighted gene co-expression network analysis allowed extraction of gene signatures associated with tissue phenotypes from ROI annotations. Nanostring GeoMx DSP data therefore require alternative normalization methods and analysis pipelines." @default.
• W4313453642 created "2023-01-06" @default.
• W4313453642 creator A5000773189 @default.
• W4313453642 creator A5016295167 @default.
• W4313453642 creator A5022651335 @default.
• W4313453642 creator A5047392477 @default.
• W4313453642 creator A5066536206 @default.
• W4313453642 creator A5081914769 @default.
• W4313453642 creator A5091396880 @default.
• W4313453642 date "2023-01-01" @default.
• W4313453642 modified "2023-10-14" @default.
• W4313453642 title "Alternative normalization and analysis pipeline to address systematic bias in NanoString GeoMx Digital Spatial Profiling data" @default.
• W4313453642 cites W1966327575 @default.
• W4313453642 cites W2040458067 @default.
• W4313453642 cites W2179438025 @default.
• W4313453642 cites W2318935314 @default.
• W4313453642 cites W2806989085 @default.
• W4313453642 cites W2961217357 @default.
• W4313453642 cites W2981596310 @default.
• W4313453642 cites W3130848196 @default.
• W4313453642 cites W3134382826 @default.
• W4313453642 cites W3136070537 @default.
• W4313453642 cites W3145026833 @default.
• W4313453642 cites W3157263169 @default.
• W4313453642 cites W3165863602 @default.
• W4313453642 cites W3189272102 @default.
• W4313453642 cites W3197670201 @default.
• W4313453642 cites W4226197469 @default.
• W4313453642 cites W4233578221 @default.
• W4313453642 doi "https://doi.org/10.1016/j.isci.2022.105760" @default.
• W4313453642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36590163" @default.
• W4313453642 hasPublicationYear "2023" @default.
• W4313453642 type Work @default.
• W4313453642 citedByCount "1" @default.
• W4313453642 countsByYear W43134536422023 @default.
• W4313453642 crossrefType "journal-article" @default.
• W4313453642 hasAuthorship W4313453642A5000773189 @default.
• W4313453642 hasAuthorship W4313453642A5016295167 @default.
• W4313453642 hasAuthorship W4313453642A5022651335 @default.
• W4313453642 hasAuthorship W4313453642A5047392477 @default.
• W4313453642 hasAuthorship W4313453642A5066536206 @default.
• W4313453642 hasAuthorship W4313453642A5081914769 @default.
• W4313453642 hasAuthorship W4313453642A5091396880 @default.
• W4313453642 hasBestOaLocation W43134536421 @default.
• W4313453642 hasConcept C105795698 @default.
• W4313453642 hasConcept C111919701 @default.
• W4313453642 hasConcept C118671147 @default.
• W4313453642 hasConcept C124101348 @default.
• W4313453642 hasConcept C136886441 @default.
• W4313453642 hasConcept C144024400 @default.
• W4313453642 hasConcept C153180895 @default.
• W4313453642 hasConcept C154945302 @default.
• W4313453642 hasConcept C162984825 @default.
• W4313453642 hasConcept C187191949 @default.
• W4313453642 hasConcept C19165224 @default.
• W4313453642 hasConcept C2777466982 @default.
• W4313453642 hasConcept C2779473830 @default.
• W4313453642 hasConcept C2781162219 @default.
• W4313453642 hasConcept C33923547 @default.
• W4313453642 hasConcept C41008148 @default.
• W4313453642 hasConcept C55493867 @default.
• W4313453642 hasConcept C70721500 @default.
• W4313453642 hasConcept C86803240 @default.
• W4313453642 hasConceptScore W4313453642C105795698 @default.
• W4313453642 hasConceptScore W4313453642C111919701 @default.
• W4313453642 hasConceptScore W4313453642C118671147 @default.
• W4313453642 hasConceptScore W4313453642C124101348 @default.
• W4313453642 hasConceptScore W4313453642C136886441 @default.
• W4313453642 hasConceptScore W4313453642C144024400 @default.
• W4313453642 hasConceptScore W4313453642C153180895 @default.
• W4313453642 hasConceptScore W4313453642C154945302 @default.
• W4313453642 hasConceptScore W4313453642C162984825 @default.
• W4313453642 hasConceptScore W4313453642C187191949 @default.
• W4313453642 hasConceptScore W4313453642C19165224 @default.
• W4313453642 hasConceptScore W4313453642C2777466982 @default.
• W4313453642 hasConceptScore W4313453642C2779473830 @default.
• W4313453642 hasConceptScore W4313453642C2781162219 @default.
• W4313453642 hasConceptScore W4313453642C33923547 @default.
• W4313453642 hasConceptScore W4313453642C41008148 @default.
• W4313453642 hasConceptScore W4313453642C55493867 @default.
• W4313453642 hasConceptScore W4313453642C70721500 @default.
• W4313453642 hasConceptScore W4313453642C86803240 @default.
• W4313453642 hasIssue "1" @default.
• W4313453642 hasLocation W43134536421 @default.
• W4313453642 hasLocation W43134536422 @default.
• W4313453642 hasLocation W43134536423 @default.
• W4313453642 hasLocation W43134536424 @default.
• W4313453642 hasOpenAccess W4313453642 @default.
• W4313453642 hasPrimaryLocation W43134536421 @default.
• W4313453642 hasRelatedWork W1558963043 @default.
• W4313453642 hasRelatedWork W1566685310 @default.
• W4313453642 hasRelatedWork W2054080489 @default.
• W4313453642 hasRelatedWork W2099646341 @default.
• W4313453642 hasRelatedWork W2105379157 @default.
• W4313453642 hasRelatedWork W2189651794 @default.
• W4313453642 hasRelatedWork W2690313894 @default.
• W4313453642 hasRelatedWork W3111311846 @default.
• W4313453642 hasRelatedWork W4200420744 @default.

• next