FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313453691> ?p ?o ?g. }

• W4313453691 abstract "Abstract The narrow escape theory (NET) predicts the escape time distribution of Brownian particles confined to a domain with reflecting borders except for one small window. Applications include molecular activation events in cell biology and biophysics. Specifically, the mean first passage time can be analytically calculated from the size of the domain, the escape window, and the diffusion coefficient of the particles. In this study, we systematically tested the NET in a disc by variation of the escape opening. Our model system consisted of micro-patterned lipid bilayers. For the measurement of , we imaged diffusing fluorescently-labeled lipids using single-molecule fluorescence microscopy. We overcame the lifetime limitation of fluorescent probes by re-scaling the measured time with the fraction of escaped particles. Experiments were complemented by matching stochastic numerical simulations. To conclude, we confirmed the NET prediction in vitro and in silico for the disc geometry in the limit of small escape openings. Significance Statement In the biological context of a cell, a multitude of reactions are facilitated by diffusion. It is astonishing how Brownian motion as a cost-efficient but random process is mediating especially fast reactions. The formalism of the narrow escape theory is a tool to determine the average timescale of such processes to be completed (mean first passage time, MFPT) from the reaction space and diffusion coefficient. We present the systematic proof of this formalism experimentally in a bio-mimetic model system and by random walk simulations. Further, we demonstrate a straightforward solution to determine the MFPT from incomplete experimental traces. This will be beneficial for measurements of the MFPT, reliant on fluorescent probes, that have prior been inaccessible." @default.
• W4313453691 created "2023-01-06" @default.
• W4313453691 creator A5006152136 @default.
• W4313453691 creator A5022382712 @default.
• W4313453691 creator A5042777833 @default.
• W4313453691 creator A5076240676 @default.
• W4313453691 creator A5090374920 @default.
• W4313453691 date "2023-01-03" @default.
• W4313453691 modified "2023-09-25" @default.
• W4313453691 title "Experiments in micro-patterned model membranes support the narrow escape theory" @default.
• W4313453691 cites W187666043 @default.
• W4313453691 cites W1918130790 @default.
• W4313453691 cites W1973744445 @default.
• W4313453691 cites W2007264976 @default.
• W4313453691 cites W2021748684 @default.
• W4313453691 cites W2030765885 @default.
• W4313453691 cites W2035751820 @default.
• W4313453691 cites W2043335304 @default.
• W4313453691 cites W2048212809 @default.
• W4313453691 cites W2049360550 @default.
• W4313453691 cites W2051915138 @default.
• W4313453691 cites W2053012879 @default.
• W4313453691 cites W2056376882 @default.
• W4313453691 cites W2058187222 @default.
• W4313453691 cites W2059669467 @default.
• W4313453691 cites W2062552264 @default.
• W4313453691 cites W2069254136 @default.
• W4313453691 cites W2073606285 @default.
• W4313453691 cites W2084312697 @default.
• W4313453691 cites W2087801867 @default.
• W4313453691 cites W2094689330 @default.
• W4313453691 cites W2099910260 @default.
• W4313453691 cites W2113966248 @default.
• W4313453691 cites W2126136156 @default.
• W4313453691 cites W2132036867 @default.
• W4313453691 cites W2139279857 @default.
• W4313453691 cites W2141542600 @default.
• W4313453691 cites W2143381397 @default.
• W4313453691 cites W2170103257 @default.
• W4313453691 cites W2180171939 @default.
• W4313453691 cites W2295748681 @default.
• W4313453691 cites W2335570095 @default.
• W4313453691 cites W2565730641 @default.
• W4313453691 cites W2754413319 @default.
• W4313453691 cites W2789728392 @default.
• W4313453691 cites W2901447493 @default.
• W4313453691 cites W2921842275 @default.
• W4313453691 cites W2963891425 @default.
• W4313453691 cites W2998579538 @default.
• W4313453691 cites W3095912021 @default.
• W4313453691 cites W3134018100 @default.
• W4313453691 cites W3198928856 @default.
• W4313453691 doi "https://doi.org/10.1101/2023.01.03.521408" @default.
• W4313453691 hasPublicationYear "2023" @default.
• W4313453691 type Work @default.
• W4313453691 citedByCount "1" @default.
• W4313453691 countsByYear W43134536912023 @default.
• W4313453691 crossrefType "posted-content" @default.
• W4313453691 hasAuthorship W4313453691A5006152136 @default.
• W4313453691 hasAuthorship W4313453691A5022382712 @default.
• W4313453691 hasAuthorship W4313453691A5042777833 @default.
• W4313453691 hasAuthorship W4313453691A5076240676 @default.
• W4313453691 hasAuthorship W4313453691A5090374920 @default.
• W4313453691 hasBestOaLocation W43134536911 @default.
• W4313453691 hasConcept C105795698 @default.
• W4313453691 hasConcept C112401455 @default.
• W4313453691 hasConcept C121194460 @default.
• W4313453691 hasConcept C121332964 @default.
• W4313453691 hasConcept C121864883 @default.
• W4313453691 hasConcept C12554922 @default.
• W4313453691 hasConcept C151730666 @default.
• W4313453691 hasConcept C185592680 @default.
• W4313453691 hasConcept C186060115 @default.
• W4313453691 hasConcept C186659197 @default.
• W4313453691 hasConcept C2524010 @default.
• W4313453691 hasConcept C2779343474 @default.
• W4313453691 hasConcept C33923547 @default.
• W4313453691 hasConcept C62520636 @default.
• W4313453691 hasConcept C69357855 @default.
• W4313453691 hasConcept C8272713 @default.
• W4313453691 hasConcept C86803240 @default.
• W4313453691 hasConcept C97355855 @default.
• W4313453691 hasConcept C99844830 @default.
• W4313453691 hasConceptScore W4313453691C105795698 @default.
• W4313453691 hasConceptScore W4313453691C112401455 @default.
• W4313453691 hasConceptScore W4313453691C121194460 @default.
• W4313453691 hasConceptScore W4313453691C121332964 @default.
• W4313453691 hasConceptScore W4313453691C121864883 @default.
• W4313453691 hasConceptScore W4313453691C12554922 @default.
• W4313453691 hasConceptScore W4313453691C151730666 @default.
• W4313453691 hasConceptScore W4313453691C185592680 @default.
• W4313453691 hasConceptScore W4313453691C186060115 @default.
• W4313453691 hasConceptScore W4313453691C186659197 @default.
• W4313453691 hasConceptScore W4313453691C2524010 @default.
• W4313453691 hasConceptScore W4313453691C2779343474 @default.
• W4313453691 hasConceptScore W4313453691C33923547 @default.
• W4313453691 hasConceptScore W4313453691C62520636 @default.
• W4313453691 hasConceptScore W4313453691C69357855 @default.
• W4313453691 hasConceptScore W4313453691C8272713 @default.
• W4313453691 hasConceptScore W4313453691C86803240 @default.

• next