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- W4313453698 abstract "Interferon-gamma release assays (IGRAs) that measure pathogen-specific T-cell response rates can provide a more reliable estimate of protection than specific antibody levels but have limited potential for widespread use due to their workflow, personnel, and instrumentation demands. The major vaccines for SARS-CoV-2 have demonstrated substantial efficacy against all of its current variants, but approaches are needed to determine how these vaccines will perform against future variants, as they arise, to inform vaccine and public health policies. Here we describe a rapid, sensitive, nanolayer polylysine-integrated microfluidic chip IGRA read by a fluorescent microscope that has a 5 h sample-to-answer time and uses ∼25 μL of a fingerstick whole blood sample. Results from this assay correlated with those of a comparable clinical IGRA when used to evaluate the T-cell response to SARS-CoV-2 peptides in a population of vaccinated and/or infected individuals. Notably, this streamlined and inexpensive assay is suitable for high-throughput analyses in resource-limited settings for other infectious diseases." @default.
- W4313453698 created "2023-01-06" @default.
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- W4313453698 date "2023-01-03" @default.
- W4313453698 modified "2023-10-15" @default.
- W4313453698 title "Evaluation of SARS-CoV-2-Specific T-Cell Activation with a Rapid On-Chip IGRA" @default.
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- W4313453698 doi "https://doi.org/10.1021/acsnano.2c09018" @default.
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- W4313453698 hasPublicationYear "2023" @default.
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