FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313453963> ?p ?o ?g. }

• W4313453963 abstract "Abstract Rheumatoid arthritis (RA) is an autoimmune polyarthritis in which synovial fibroblasts (SF) play a major role in cartilage and bone destruction through tumorlike proliferation, migration, and invasion. Nesfatin-1, an 82-amino-acid-long peptide discovered by Oh-I in 2006, is derived from the precursor protein nucleobindin-2 (NUCB2). NUCB2/nesfatin-1 promotes cell proliferation, migration, and invasion in various tumors. We have previously shown that increased nesfatin-1 levels in the synovium may be associated with disease severity in patients with RA. However, the effect of NUCB2 on the tumorlike transformation of RASF has not yet been reported. The expression of NUCB2 mRNA in the synovium of RA and non-RA patients was further confirmed using three individual datasets from the NCBI GEO database. Gene set enrichment analysis (GSEA) was employed to explore the association between NUCB2 mRNA and RA-related gene signatures or signaling pathways in the GSE77298 dataset. Cell proliferation, migration, and invasion abilities were determined using Cell Counting Kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU), wound healing, and transwell assays, respectively. The results showed that the levels of NUCB2 mRNA in the synovium were significantly elevated in patients with RA. Moreover, GSEA showed that high expression of NUCB2 mRNA was related to gene signatures, including those involved in the cell cycle, DNA replication, extracellular matrix–receptor interaction, and focal adhesion. Furthermore, the results of CCK-8 and EdU assays indicated that inhibition of NUCB2 markedly repressed RASF proliferation. Additionally, the results of wound healing and transwell assays demonstrated that inhibition of NUCB2 significantly suppressed the migratory and invasive abilities of RASFs. Our findings are the first to demonstrate that the inhibition of NUCB2 suppresses the proliferation, migration, and invasion of RASFs in vitro." @default.
• W4313453963 created "2023-01-06" @default.
• W4313453963 creator A5035701638 @default.
• W4313453963 creator A5041411679 @default.
• W4313453963 creator A5069509911 @default.
• W4313453963 creator A5082924617 @default.
• W4313453963 creator A5085836753 @default.
• W4313453963 date "2022-12-30" @default.
• W4313453963 modified "2023-10-14" @default.
• W4313453963 title "Inhibition of NUCB2 suppresses the proliferation, migration, and invasion of rheumatoid arthritis synovial fibroblasts from patients with rheumatoid arthritis in vitro" @default.
• W4313453963 cites W1971295345 @default.
• W4313453963 cites W1987531086 @default.
• W4313453963 cites W1995836442 @default.
• W4313453963 cites W2000468514 @default.
• W4313453963 cites W2005246753 @default.
• W4313453963 cites W2012819770 @default.
• W4313453963 cites W2025851689 @default.
• W4313453963 cites W2040094748 @default.
• W4313453963 cites W2049220563 @default.
• W4313453963 cites W2063365729 @default.
• W4313453963 cites W2074438676 @default.
• W4313453963 cites W2089656605 @default.
• W4313453963 cites W2110192694 @default.
• W4313453963 cites W2123888073 @default.
• W4313453963 cites W2130410032 @default.
• W4313453963 cites W2137690384 @default.
• W4313453963 cites W2152746369 @default.
• W4313453963 cites W2173877678 @default.
• W4313453963 cites W2219952730 @default.
• W4313453963 cites W2235457976 @default.
• W4313453963 cites W2274668664 @default.
• W4313453963 cites W2345340946 @default.
• W4313453963 cites W2539330207 @default.
• W4313453963 cites W2789838759 @default.
• W4313453963 cites W2883856958 @default.
• W4313453963 cites W2891512849 @default.
• W4313453963 cites W2893656415 @default.
• W4313453963 cites W2896737957 @default.
• W4313453963 cites W2914784339 @default.
• W4313453963 cites W2938629106 @default.
• W4313453963 cites W2943229766 @default.
• W4313453963 cites W2981561017 @default.
• W4313453963 cites W2983841864 @default.
• W4313453963 cites W3015836180 @default.
• W4313453963 cites W3088969936 @default.
• W4313453963 cites W3126020758 @default.
• W4313453963 cites W3133983361 @default.
• W4313453963 cites W3164404386 @default.
• W4313453963 cites W3186104532 @default.
• W4313453963 cites W3192249937 @default.
• W4313453963 cites W3198271897 @default.
• W4313453963 cites W4210968471 @default.
• W4313453963 cites W54474866 @default.
• W4313453963 cites W3131336803 @default.
• W4313453963 doi "https://doi.org/10.1186/s13018-022-03453-2" @default.
• W4313453963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36585713" @default.
• W4313453963 hasPublicationYear "2022" @default.
• W4313453963 type Work @default.
• W4313453963 citedByCount "1" @default.
• W4313453963 countsByYear W43134539632023 @default.
• W4313453963 crossrefType "journal-article" @default.
• W4313453963 hasAuthorship W4313453963A5035701638 @default.
• W4313453963 hasAuthorship W4313453963A5041411679 @default.
• W4313453963 hasAuthorship W4313453963A5069509911 @default.
• W4313453963 hasAuthorship W4313453963A5082924617 @default.
• W4313453963 hasAuthorship W4313453963A5085836753 @default.
• W4313453963 hasBestOaLocation W43134539631 @default.
• W4313453963 hasConcept C105702510 @default.
• W4313453963 hasConcept C137738243 @default.
• W4313453963 hasConcept C1491633281 @default.
• W4313453963 hasConcept C189165786 @default.
• W4313453963 hasConcept C203014093 @default.
• W4313453963 hasConcept C2777077863 @default.
• W4313453963 hasConcept C2777575956 @default.
• W4313453963 hasConcept C2778917330 @default.
• W4313453963 hasConcept C2780269544 @default.
• W4313453963 hasConcept C2780550940 @default.
• W4313453963 hasConcept C502942594 @default.
• W4313453963 hasConcept C54355233 @default.
• W4313453963 hasConcept C62112901 @default.
• W4313453963 hasConcept C71924100 @default.
• W4313453963 hasConcept C86803240 @default.
• W4313453963 hasConcept C95444343 @default.
• W4313453963 hasConceptScore W4313453963C105702510 @default.
• W4313453963 hasConceptScore W4313453963C137738243 @default.
• W4313453963 hasConceptScore W4313453963C1491633281 @default.
• W4313453963 hasConceptScore W4313453963C189165786 @default.
• W4313453963 hasConceptScore W4313453963C203014093 @default.
• W4313453963 hasConceptScore W4313453963C2777077863 @default.
• W4313453963 hasConceptScore W4313453963C2777575956 @default.
• W4313453963 hasConceptScore W4313453963C2778917330 @default.
• W4313453963 hasConceptScore W4313453963C2780269544 @default.
• W4313453963 hasConceptScore W4313453963C2780550940 @default.
• W4313453963 hasConceptScore W4313453963C502942594 @default.
• W4313453963 hasConceptScore W4313453963C54355233 @default.
• W4313453963 hasConceptScore W4313453963C62112901 @default.
• W4313453963 hasConceptScore W4313453963C71924100 @default.
• W4313453963 hasConceptScore W4313453963C86803240 @default.
• W4313453963 hasConceptScore W4313453963C95444343 @default.
• W4313453963 hasFunder F4320321001 @default.

• next