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• W4313454028 abstract "Purpose To investigate age-related changes of the outer nuclear layer (ONL) thickness and cone density, and their associations in healthy participants using a modified, narrow scan-angle Heidelberg Retina Angiograph (HRA2). Methods Retinal cones were imaged outside the fovea at 8.8° eccentricity and cone density was compared to ONL thickness measurements obtained by Spectral-Domain Optical Coherence Tomography (SD-OCT) at the same locations. Fifty-six eyes of 56 healthy participants with a median age (interquartile range, IQR) of 37 years (29–55) were included. Results Median (IQR) cone count was 7,472 (7,188, 7,746) cones/mm 2 and median (IQR) ONL thickness was 56 (52, 60) µm for healthy participants. Both cone density and ONL thickness were negatively associated with age: cone density, R 2 = 0.16 (F(1,54) = 10.41, P = 0.002); ONL thickness, R 2 = 0.12 (F(1,54) = 7.41, P = 0.009). No significant association was seen between cone density and ONL thickness (R 2 = 0.03; F(1,54) = 1.66, P = 0.20). Conclusion Cone density was lower, and ONL thinner, in older compared to younger participants, therefore, image-based structural measures should be compared to age-related data. However, cone density and ONL thickness were not strongly associated, indicating that determinants of ONL thickness measurements other than cone density measurements, and including measurement error, have a major influence." @default.
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• W4313454028 date "2023-01-02" @default.
• W4313454028 modified "2023-10-14" @default.
• W4313454028 title "Ageing changes in retinal outer nuclear layer thickness and cone photoreceptor density using adaptive optics-free imaging" @default.
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• W4313454028 doi "https://doi.org/10.1177/11206721221144477" @default.
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