Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313454039> ?p ?o ?g. }
- W4313454039 endingPage "528" @default.
- W4313454039 startingPage "521" @default.
- W4313454039 abstract "We aimed to investigate immunohistochemical expression of the p53 tumor suppressor protein, and the B-cell lymphoma-2 (Bcl-2) apoptotic protein in colorectal adenocarcinoma patients with or without type 2 diabetes mellitus (T2DM). Tissue sections from 95 paraffin-embedded colorectal adenocarcinomas, originating from 52 T2DM and 43 non-diabetic patients, were immunostained for p53 [Ventana mouse monoclonal primary antibody (mAb) in vitro diagnostic (IVD) anti-p53, clone Bp53-11] and Bcl-2 (Ventana mAb IVD anti-Bcl-2, clone Bcl-2/124). Immunohistochemistry analysis did not find statistically significant differences between the two groups, but analysis on subgroups of patients in terms of presence or absence of obesity identified overexpression of p53 (>70% of cells) in the T2DM obese patients compared to non-diabetics. Overexpression of p53 was present in 80% of tumor cells coming from T2DM obese patients compared to 37.2% of tumor cells coming from non-diabetics obese and non-obese, and in 36.6% of tumor cells coming from non-diabetic non-obese patients (p=0.024). There was a single non-diabetic obese patient with p53 overexpression. Most cancer cells of T2DM obese patients presented more frequently p53 overexpression by comparison with cancer cells of the T2DM non-obese patients (80% vs 40.5%, p=0.028). Bcl-2/p53 co-expression was an infrequent event in T2DM patients' group. The results of this study suggest that patients with colorectal adenocarcinoma that associate T2DM and obesity exhibit higher p53 protein expression in malignant cells. In conclusion, our research highlights that obesity is a potential key factor in the relationship between T2DM and colorectal cancer." @default.
- W4313454039 created "2023-01-06" @default.
- W4313454039 creator A5002720152 @default.
- W4313454039 creator A5008896712 @default.
- W4313454039 creator A5022153469 @default.
- W4313454039 creator A5027089813 @default.
- W4313454039 creator A5027186213 @default.
- W4313454039 creator A5029506142 @default.
- W4313454039 creator A5045371151 @default.
- W4313454039 creator A5049681717 @default.
- W4313454039 creator A5075398665 @default.
- W4313454039 date "2022-12-28" @default.
- W4313454039 modified "2023-10-18" @default.
- W4313454039 title "Bcl-2 and p53 immunophenotypes in colorectal adenocarcinoma in type 2 diabetes mellitus versus non-diabetic patients" @default.
- W4313454039 cites W129697205 @default.
- W4313454039 cites W1906462579 @default.
- W4313454039 cites W1920952588 @default.
- W4313454039 cites W1966346152 @default.
- W4313454039 cites W1968234252 @default.
- W4313454039 cites W1975090615 @default.
- W4313454039 cites W1977531766 @default.
- W4313454039 cites W1978012243 @default.
- W4313454039 cites W1990436525 @default.
- W4313454039 cites W1999848695 @default.
- W4313454039 cites W2002004237 @default.
- W4313454039 cites W2008538525 @default.
- W4313454039 cites W2031363351 @default.
- W4313454039 cites W2033737920 @default.
- W4313454039 cites W2038502978 @default.
- W4313454039 cites W2043676782 @default.
- W4313454039 cites W2050889736 @default.
- W4313454039 cites W2053613912 @default.
- W4313454039 cites W2057057259 @default.
- W4313454039 cites W2057580164 @default.
- W4313454039 cites W2058431917 @default.
- W4313454039 cites W2060619528 @default.
- W4313454039 cites W2062450769 @default.
- W4313454039 cites W2066809635 @default.
- W4313454039 cites W2071707853 @default.
- W4313454039 cites W2072554852 @default.
- W4313454039 cites W2073352138 @default.
- W4313454039 cites W2078224872 @default.
- W4313454039 cites W2079673038 @default.
- W4313454039 cites W2082421671 @default.
- W4313454039 cites W2096686828 @default.
- W4313454039 cites W2100125385 @default.
- W4313454039 cites W2103616303 @default.
- W4313454039 cites W2104528130 @default.
- W4313454039 cites W2108966286 @default.
- W4313454039 cites W2111304515 @default.
- W4313454039 cites W2112131001 @default.
- W4313454039 cites W2117840705 @default.
- W4313454039 cites W2118033619 @default.
- W4313454039 cites W2118746891 @default.
- W4313454039 cites W2119541125 @default.
- W4313454039 cites W2120775866 @default.
- W4313454039 cites W2139576101 @default.
- W4313454039 cites W2141548682 @default.
- W4313454039 cites W2144888610 @default.
- W4313454039 cites W2145108528 @default.
- W4313454039 cites W2147294934 @default.
- W4313454039 cites W2151439322 @default.
- W4313454039 cites W2166208516 @default.
- W4313454039 cites W2258204764 @default.
- W4313454039 cites W2279588415 @default.
- W4313454039 cites W2290255978 @default.
- W4313454039 cites W2336484335 @default.
- W4313454039 cites W2397635168 @default.
- W4313454039 cites W2422103947 @default.
- W4313454039 cites W2511481511 @default.
- W4313454039 cites W2568726620 @default.
- W4313454039 cites W2579159366 @default.
- W4313454039 cites W2589496748 @default.
- W4313454039 cites W2608610690 @default.
- W4313454039 cites W2611392932 @default.
- W4313454039 cites W2616453324 @default.
- W4313454039 cites W2619384557 @default.
- W4313454039 cites W2765843462 @default.
- W4313454039 cites W2895977992 @default.
- W4313454039 cites W2916911849 @default.
- W4313454039 cites W2947862922 @default.
- W4313454039 cites W3039529906 @default.
- W4313454039 cites W785937037 @default.
- W4313454039 cites W962625150 @default.
- W4313454039 cites W1940590316 @default.
- W4313454039 cites W1970070562 @default.
- W4313454039 doi "https://doi.org/10.47162/rjme.63.3.06" @default.
- W4313454039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36588490" @default.
- W4313454039 hasPublicationYear "2022" @default.
- W4313454039 type Work @default.
- W4313454039 citedByCount "0" @default.
- W4313454039 crossrefType "journal-article" @default.
- W4313454039 hasAuthorship W4313454039A5002720152 @default.
- W4313454039 hasAuthorship W4313454039A5008896712 @default.
- W4313454039 hasAuthorship W4313454039A5022153469 @default.
- W4313454039 hasAuthorship W4313454039A5027089813 @default.
- W4313454039 hasAuthorship W4313454039A5027186213 @default.
- W4313454039 hasAuthorship W4313454039A5029506142 @default.